40035-78-7

Upstream product

• 95931-50-3 5-(3-Acetamidophenyl)-2-methylpyridine 
• 63843-15-2 4-[1-(6-Methyl-pyridin-3-yl)-vinyl]-morpholine 
• 63843-17-4 3-(2-Methyl-5-pyridinyl)-2-cyclohexen-1-one 
• 36357-38-7 1-(6-methyl-pyridin-3-yl)-ethanone 
• 63843-21-0 3-(2-Methyl-5-pyridyl)-2-cyclohexen-1-one oxime 

Downstream Products

• 40035-77-6 2-{[3-(6-Methyl-pyridin-3-yl)-phenylamino]-methylene}-malonic acid diethyl ester 

Relevant academic research and scientific papers

3-(Pyridinyl)-2-cyclohexen-1-ones

3-(4 OR 3-Pyridinyl)-2-cyclohexen-1-ones (I) and their oxime derivatives are useful in preparing (3-aminophenyl)-pyridines, in turn, useful in preparing known antibacterial agents. Also shown is the preparation of I by starting with the reaction of methyl vinyl ketone with either 1-(pyridinyl)-1-(lower-tertiary-amino)-ethylene (II) or lower-alkyl 3-(pyridinyl)-3-oxopropanoate. Also shown is the process of converting I to its oxime, acylating the oxime and heating the acylated oxime under acidic conditions to produce N-(lower-acyl)-3-(pyridinyl)-aniline (VII), and hydrolyzing VII under aqueous alkaline conditions to produce the corresponding 3-(pyridinyl)aniline.