40042-06-6

Basic information

• Product Name: 2,3,4,7-tetraacetoxy-cis-dihydronarciclasine
• Synonyms: 2,3,4,7-tetraacetoxy-cis-dihydronarciclasine
• CAS NO: 40042-06-6
• Molecular Weight: 477.425
• Mol File: 40042-06-6.mol

Chemical Properties

• CAS DataBase Reference: 2,3,4,7-tetraacetoxy-cis-dihydronarciclasine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,7-tetraacetoxy-cis-dihydronarciclasine(40042-06-6)
• EPA Substance Registry System: 2,3,4,7-tetraacetoxy-cis-dihydronarciclasine(40042-06-6)

Safety Data

• Hazardous Substances Data: 40042-06-6(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 29477-83-6 narciclasine 

Relevant articles and documents

Human cytochrome P450 liability studies of trans-dihydronarciclasine: A readily available, potent, and selective cancer cell growth inhibitor

The cytochrome P45O activities of the naturally occurring Amaryllidaceae alkaloid narciclasine (3), isolated from Narcissus pseudonarcissus, and synthetic derivative trans-dihydronarciclasine (5) are reported. While narciclasine was found to possess potent inhibitory activity to human CYP3A4, its dihydro analogue was inactive. This study revealed that the C1-C10b double bond is required for inhibition of this crucial metabolizing enzyme. Compound 5 also demonstrated no inhibition of the related human cytochromes CYP19 and CYP1A1. This study elevates the status of trans-dihydronarciclasine (5) as a highly privileged, readily available molecule, with potent and selective anticancer activity.