40047-20-9

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 100-44-7 benzyl chloride 
• 869900-40-3 2-azido-3-(4-benzyloxyphenyl)acrylic acid ethyl ester 
• 4397-53-9 p-benzyloxybenzaldehyde 

Downstream Products

• 1150742-73-6 6-benzyloxy-1-methoxymethyl-1H-indole-2-carboxylic acid ethyl ester 
• 1262029-58-2 C₁₆H₁₅NO₂ 
• 1262029-59-3 C₆H₅CH₂OC₈NH₅CH₂C₄NH₂(CH₃)2 
• 902757-12-4 6-benzyloxy-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester 
• 98424-32-9 acetylamino-(6-benzyloxy-indol-3-ylmethyl)-malonic acid diethyl ester 
• 94875-04-4 6-Benzyloxy-3-(2-acetamino-2,2-dicarboxy-ethyl)-indol 
• 88208-17-7 3-(6-benzyloxy-1H-indol-3-yl)-2-acetylaminopropionic acid 
• 57765-22-7 3-(dimethylaminomethyl)-6-benzyloxyindole 
• 15903-94-3 6-benzyloxy-1H-indole 
• 909699-85-0 2-(6-benzyloxy-1H-indol-3-ylmethyl)-2-(4-chloro-benzoylamino)-malonic acid diethyl ester 
• 909699-89-4 2-(6-benzyloxy-1H-indol-3-ylmethyl)-2-phenylacetylamino-malonic acid diethyl ester 
• 909699-79-2 2-(6-benzyloxy-1H-indol-3-ylmethyl)-2-(4-chloro-benzoylamino)-malonic acid 
• 909699-86-1 2-benzoylamino-2-(6-benzyloxy-1H-indol-3-ylmethyl)-malonic acid diethyl ester 
• 909699-90-7 2-(6-benzyloxy-1H-indol-3-ylmethyl)-2-phenylacetylamino-malonic acid 

Relevant academic research and scientific papers

Development of an indole-based boron-dipyrromethene fluorescent probe for benzenethiols

Discrimination between chemically related benzenethiols and aliphatic thiols represents a big problem. In this paper, a fluorescent probe, Bodipy-1, containing an indole-based Bodipy as a fluorophore and a 2,4- dinitrobenzenesulfonyl group as a recognition unit was constructed to achieve the selectivity between them. The Bodipy group in the prepared probe was selectively released through aromatic nucleophilic substitution by thiolate anions from benzenethiols, resulting in blue-red switching in the emission spectra in buffer solutions; that is, two new peaks of the phenol/phenolate state of Bodipy-2 at 565 and 629 nm appeared in emission spectra. By varying the pH value from 6.6 to 8.8, the intensity ratio of I565/I 629 varies from 2.0 to 0.3 after complete conversion to Bodipy-2, a ca. 7-fold emission ratio change. This ratiometric emission property by varying the pH value makes Bodipy-1 a promising probe to discriminate benzenethiols from aliphatic thiols by careful selection of the reaction pH.

INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), Wherein X1 , R1 , R2 , R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARγ ligands (I)

MCSS and LeapFrog, two de novo drug design programs, were used for the novel indole-based PPARγ ligands' study. The designed compounds were synthesized and tested for the PPARγ protein binding activities in vitro. Out of the compounds that were synthesize