40054-65-7

Upstream product

• 29462-27-9 [2-(2-bromo-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophen-3-yl]-phenyl-methanone 
• 29462-18-8 bentazepam 

Downstream Products

• 40054-80-6 6-phenyl-7,8,9,10-tetrahydro-4H-benzo[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine 

Relevant academic research and scientific papers

Syntheses and structure-activity relationships of 6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e][1,4]diazepines

A variety of 6 aryl 4H s triazolo [3,4-c]thieno [2,3-e] [1,4]diazepines was synthesized and tested for anti-pentylenetetrazole activity and inhibition of fighting episodes. The structure-activity relationships are discussed. Some compounds were more active than diazepam in the two assays. Among them, 6 (o chlorophenyl) 8 ethyl 1 methyl 4H s triazolo [3,4-c] thieno [2,3-e][1,4] diazepine was found to have favourable properties as an anxiolytic drug with very low toxicity. Clinical studies of this compound (Y-7131) are under way.

Synthesis and pharmacological evaluation of 2,3 dihydro 1H thieno[2,3 e][1,4]diazepines

A series of 2,3 dihydro 1H thieno[2,3 e][1,4]diazepines was synthesized and evaluated for CNS activity. A new antianxiety screen for benzodiazepine like drugs was used along with the standard anticonvulsant test. Structure activity relationships are discussed. One compound, 1,3,6,7,8,9 hexahydro 5 phenyl 2H [1]benzothieno[2,3 e][1,4]diazepin 2 one monosulfate (CI 718), is undergoing clinical studies in man.