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Etizolam, a thienodiazepine benzodiazepine derivative, is a potent anxiolytic with amnesic, anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties. It acts on the benzodiazepine site of the GABA-A receptor as an agonist, increasing inhibitory GABAergic transmission throughout the central nervous system. Etizolam is closely related to brotizolam and pharmacologically resembles diazepam. It is also known to have an effect on monoamine metabolism in the brain.

40054-69-1

40054-69-1 Suppliers

This product is a nationally controlled contraband or patented product, and the Lookchem platform doesn't provide relevant sales information.

40054-69-1 Hazards Identification

Pictogram(s):

Signal:

Danger

GHS Hazard Statements:

H315 (59.38%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (59.38%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H360 (37.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]

Precautionary Statement Codes:

P203, P264, P264+P265, P280, P302+P352, P305+P351+P338, P318, P321, P332+P317, P337+P317, P362+P364, P405, and P501

Hazard Classes and Categories:

Skin Irrit. 2 (59.38%)
Eye Irrit. 2 (59.38%)
Repr. 1B (37.5%)

40054-69-1 Usage

Uses

Used in Pharmaceutical Industry:
Etizolam is used as a short-term treatment for insomnia, anxiety, or panic attacks due to its anxiolytic, sedative, and muscle relaxant properties.
Used in Nasal Dilator Applications:
Etizolam is used as a nasal dilator for its muscle relaxant properties, which can help alleviate nasal congestion and improve breathing.

References

https://www.drugbank.ca/drugs/DB09166 https://en.wikipedia.org/wiki/Etizolam Casacchia, Massimo, F. Bolino, and U. Ecari. "Etizolam in the treatment of generalized anxiety disorder: a double-blind study versus placebo."Current Medical Research & Opinion 12.4(2008):215-223. Savoldi, F, G. Somenzini, and U. Ecari. "Etizolam versus placebo in the treatment of panic disorder with agoraphobia: a double-blind study."Current Medical Research & Opinion 12.3(1990):185. Hirashima, Y, et al. "Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography." Neurologia medico-chirurgica 42.2(2002):53-55.

Originator

Yoshitomi (Japan)

Check Digit Verification of cas no

The CAS Registry Mumber 40054-69-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,0,5 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 40054-69:
(7*4)+(6*0)+(5*0)+(4*5)+(3*4)+(2*6)+(1*9)=81
81 % 10 = 1
So 40054-69-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3

40054-69-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Etizolam

1.2 Other means of identification

Product number -
Other names 4-(2-chloro-phenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40054-69-1 SDS

40054-69-1Relevant academic research and scientific papers

Syntheses and structure-activity relationships of 6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e][1,4]diazepines

Tahara,Araki,Shiroki,Matsuo,Munakata

, p. 1153 - 1158 (2007/10/08)

A variety of 6 aryl 4H s triazolo [3,4-c]thieno [2,3-e] [1,4]diazepines was synthesized and tested for anti-pentylenetetrazole activity and inhibition of fighting episodes. The structure-activity relationships are discussed. Some compounds were more active than diazepam in the two assays. Among them, 6 (o chlorophenyl) 8 ethyl 1 methyl 4H s triazolo [3,4-c] thieno [2,3-e][1,4] diazepine was found to have favourable properties as an anxiolytic drug with very low toxicity. Clinical studies of this compound (Y-7131) are under way.