40055-37-6Relevant articles and documents
The stability of nicorandil in aqueous solution. I. Kinetics and mechanism of decomposition of N-(2-hydroxyethyl)nicotinamide nitrate (ester) in aqueous solution
Nagai,Kikuchi,Nagano,Shiba
, p. 1063 - 1070 (1984)
-
Nicorandil preparation method
-
Paragraph 0035-0040, (2020/04/06)
The invention discloses a nicorandil preparation method, which comprises the following steps: synthesis of 3-pyridyloxazolidine: under stirring, adding aminoethanol and a solid bromination reagent into an alcoholic solution of 3-pyridylaldehyde, stirring at room temperature until the 3-pyridylaldehyde is completely consumed, quenching the reaction system with a saturated sodium thiosulfate solution, extracting with ethyl acetate, and concentrating the organic phase to obtain a crude product 3-pyridyloxazolidine; and synthesis of nicorandil: dissolving the 3-pyridyloxazolidine in a solvent, adding nitrite, heating, introducing an oxygen-containing gas, stirring until the 3-pyridyloxazolidine is completely consumed, quenching with a saturated sodium sulfate solution, extracting with ethyl acetate, concentrating, adding the crude product into a 30% ethyl acetate n-hexane solution until dissloving, cooling to 10 DEG C, precipitating a solid, and filtering to obtain the nicorandil.
Synthesis of heterocyclic 1,3-oxazolines from aldehydes with trimethylphenylammonium tribromide
Sayama, Shinsei
, p. 979 - 990 (2017/06/13)
Various heterocyclic 1,3-oxazolines were prepared from aldehydes and aminoalcohols with trimethylphenylammonium tribromide at room temperature.