4006-73-9

Usage

Uses

1-Benzylcycloheptanol is an intermediate in the synthesis of bencyclane fumerate (B132300).

InChI:InChI=1/C14H20O/c15-14(10-6-1-2-7-11-14)12-13-8-4-3-5-9-13/h3-5,8-9,15H,1-2,6-7,10-12H2

Upstream product

• 100-44-7 benzyl chloride 
• 502-42-1 cycloheptanone 
• 101-41-7 benzeneacetic acid methyl ester 
• 17257-32-8 1-propylcycloheptanol 
• 14286-84-1 Fluxema 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 15537-52-7 1-Benzylcycloheptene 
• 2082-16-8 [2-(1-Benzyl-cycloheptyloxy)-1-methyl-ethyl]-dimethyl-amine 
• 2082-18-0 [3-(1-Benzyl-cycloheptyloxy)-2-methyl-propyl]-dimethyl-amine 
• 22710-78-7 [2-(1-Benzyl-cycloheptyloxy)-ethyl]-diisopropyl-amine 
• 22710-77-6 [3-(1-Benzyl-cycloheptyloxy)-propyl]-diethyl-amine 
• 2082-20-4 [2-(1-Benzyl-cycloheptyloxy)-ethyl]-diethyl-amine 
• 2179-37-5 bencyclane 
• 15537-53-8 (Cycloheptylidenmethyl)benzol 
• 19217-55-1 benzylcycloheptane 
• 22671-58-5 4-[3-(1-benzyl-cycloheptyloxy)-propyl]-morpholine 

Relevant academic research and scientific papers

A Selective and Functional Group-Tolerant Ruthenium-Catalyzed Olefin Metathesis/Transfer Hydrogenation Tandem Sequence Using Formic Acid as Hydrogen Source

A ruthenium-catalyzed transfer hydrogenation of olefins utilizing formic acid as a hydrogen donor is described. The application of commercially available alkylidene ruthenium complexes opens access to attractive C(sp3)-C(sp3) bond formation in an olefin metathesis/transfer hydrogenation sequence under tandem catalysis conditions. High chemoselectivity of the developed methodology provides a remarkable synthetic tool for the reduction of various functionalized alkenes under mild reaction conditions. The developed methodology is applied for the formal synthesis of the drugs pentoxyverine and bencyclane.

Photolysis of 1-alkylcycloalkanols in the presence of (diacetoxyiodo) benzene and I2. Intramolecular selectivity in the β-scission reactions of the intermediate 1-alkylcycloalkoxyl radicals

The C-C β-scission reactions of 1-alkylcycloalkoxyl radicals, generated photochemically by visible light irradiation of CH2Cl 2 solutions containing the parent 1-alkylcycloalkanols, (diacetoxy)-iodobenzene (DIB), and I2, have been investigated through the analysis of the reaction products. The 1-alkylcycloalkoxyl radicals undergo competition between ring opening and C-alkyl bond cleavage as a function of ring size and of the nature of the alkyl substituent. With the 1-propylcycloheptoxyl, 1-propylcyclooctoxyl, and 1-phenylcyclooctoxyl radicals, formation of products deriving from an intramolecular 1,5-hydrogen atom abstraction reaction from the cycloalkane ring has also been observed. The results are discussed in terms of release of ring strain associated to ring opening, stability of the alkyl radical formed by C-alkyl cleavage, and with cycloheptoxyl and cyclooctoxyl radicals, also in terms of the possibility of achieving a favorable geometry for intramolecular hydrogen atom abstraction.