400602-58-6Relevant articles and documents
Design and synthesis of Pfmrk inhibitors as potential antimalarial agents.
Xiao,Waters,Woodard,Li,Li
, p. 2875 - 2878 (2001)
The synthesis and inhibitory activities of 10 potential inhibitors of Pfmrk, a Plasmodium falciparum cyclin-dependent protein kinase, are described. The most potent inhibitor is a 3-phenyl-quinolinone compound with an IC(50) value of 18 microM. It is the first compound reported to inhibit Pfmrk at the micro molar range.