400614-20-2Relevant academic research and scientific papers
Molecular design and biological potential of galacto-type trehalose as a nonnatural ligand of shiga toxins.
Dohi, Hirofumi,Nishida, Yoshihiro,Furuta, Yuki,Uzawa, Hirotaka,Yokoyama, Shin-ichiro,Ito, Saori,Mori, Hiroshi,Kobayashi, Kazukiyo
, p. 355 - 357 (2007/10/03)
Galacto-type trehalose, a "C-4 epimer of trehalose", possesses a stereochemical structure around the alpha(1-1)-linkage analogous to that of the globobiosyl alpha(1-4)-linkage in Gb(2) and Gb(3) ceramides, which are known as the ligands of Shiga toxins produced by pathogenic E. coli. This paper presents evidence supporting the new idea of using a trehalosyl alpha(1-1)-linkage as a substitute for the galactobiosyl alpha(1-4)-linkage.
