400643-64-3

Upstream product

• 1245018-81-8 3-(t-butyl)diphenylsiloxy-17-methoxyandrostane 
• 481-29-8 Epiandrosterone 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1245773-27-6 C₃₅H₅₀OSi 
• 1224-93-7 5α-androstan-3β-ol 
• 400643-70-1 (2S,3S,5S)-5-(2-Benzyloxy-ethyl)-2-[(3S,5S,8R,9S,10S,13S,14S)-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptan-3-ol 
• 400643-71-2 (2S,3R,5S)-5-(2-Benzyloxy-ethyl)-2-[(3S,5S,8R,9S,10S,13S,14S)-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptan-3-ol 
• 400643-73-4 (2S,5S)-5-(2-Benzyloxy-ethyl)-2-[(3S,5S,8R,9S,10S,13S,14S)-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptan-3-one 
• 400643-68-7 Acetic acid (3R,5S,6S)-6-[(3S,5S,8R,9S,10S,13S,14S)-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-3-isopropyl-heptyl ester 
• 400643-69-8 Acetic acid (3R,5R,6S)-6-[(3S,5S,8R,9S,10S,13S,14S)-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-3-isopropyl-heptyl ester 
• 400643-72-3 Acetic acid (3R,6S)-6-[(3S,5S,8R,9S,10S,13S,14S)-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-isopropyl-5-oxo-heptyl ester 
• 400643-78-9 (3R,5S,6S)-6-[(3S,5S,8R,9S,10S,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-3-isopropyl-heptane-1,5-diol 
• 400643-80-3 (3S,5S,6S)-6-[(3S,5S,8R,9S,10S,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-3-isopropyl-heptane-1,5-diol 
• 400643-79-0 (3R,5R,6S)-6-[(3S,5S,8R,9S,10S,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-3-isopropyl-heptane-1,5-diol 
• 400643-81-4 (3S,5R,6S)-6-[(3S,5S,8R,9S,10S,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-3-isopropyl-heptane-1,5-diol 

Relevant academic research and scientific papers

Stereocontrolled synthesis of contignasterol's side chain

The four models of the contignasterol's side chains (2-5) have been stereospecifically prepared. The key reaction in the synthesis is a dimethylaluminum chloride-mediated 'ene' reaction between the steroid derivative 6 and the pseudo-enantiomeric aldehydes 7 and 8.

CCl3CN: A crucial promoter of M CPBA-mediated direct ether oxidation

The direct oxidation of ether sp3 C-H bonds using the new reagent system mCPBA/CCl3CN/MeCN has been developed. CCl 3CN in MeCN drastically alters the reactivity of m-chloroperbenzoic acid (mCPBA), and chemoselective transformation of methyl ethers to ketones was realized under mild conditions. Radical-based mCPBA-mediated oxidation was suggested as the reaction mechanism. The present new reaction expands the utility of methyl ethers as stable synthetic precursors of carbonyl compounds and of mCPBA as a radical-based C-H oxidizing agent.