400648-51-3Relevant articles and documents
2,3-Diphenylpropionic acids as potent VLA-4 antagonists
Hoshina, Yoichiro,Ikegami, Satoru,Okuyama, Akihiko,Fukui, Hideto,Inoguchi, Kiyoshi,Maruyama, Tatsuya,Fujimoto, Kyoko,Matsumura, Yuzuru,Aoyama, Akinori,Harada, Tatsuhiro,Tanaka, Hiroshi,Nakamura, Tsutomu
, p. 217 - 220 (2007/10/03)
2,3-Diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC50 of 1.7 nM, and has good pharmacokinetics a