40069-75-8

Usage

General Description

2(1H)-Quinazolinone, 6-chloro-4-(2-fluorophenyl)- is a chemical compound with the molecular formula C15H9ClFN3O. It is a quinazolinone derivative that contains a 6-chloro-4-(2-fluorophenyl) substituent. 2(1H)-Quinazolinone, 6-chloro-4-(2-fluorophenyl)- may have pharmaceutical applications due to its potential biological activities, such as antibacterial, antifungal, and antitumor properties. It can also be used as a building block in the synthesis of various organic compounds. Further research and analysis are necessary to explore the full potential and applications of 2(1H)-Quinazolinone, 6-chloro-4-(2-fluorophenyl)- in different fields.

Upstream product

• 40387-16-4 ethyl 4-(2-(o-fluorobenzoyl)-4-chlorophenyl)-allophanate 
• 57-13-6 urea 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 
• 40387-05-1 [4-chloro-2-(2-fluoro-benzoyl)-phenyl]-imidazolidinetrione 

Relevant academic research and scientific papers

Microwave assisted synthesis of 4-phenylquinazolin-2(1H)-one derivatives that inhibit vasopressor tonus in rat thoracic aorta

Quinazolinones have pharmacological effects on vascular reactivity through different mechanisms. We synthesized 4-phenylquinazolin-2(1H)-one derivatives under microwave irradiation and tested them on the rat thoracic aorta. The prepared compounds 2a-2f were obtained in about 1 h with suitable yields (31-92%). All derivatives produced vasorelaxant effects with IC50 values ranging from 3.41 ± 0.65 μM to 39.72 ± 6.77 μM. Compounds 2c, 2e and 2f demonstrated the highest potency in endothelium-intact aorta rings (IC50 4.31 ± 0.90 μM, 4.94 ± 1.21 μM and 3.41 ± 0.65 μM respectively), and they achieved around 90% relaxation (30 μM). In aorta rings without an endothelium, the effect of compound 2f was abolished. Using the MTT assay to test for cell viability, only compound 2b induced cytotoxicity at the maximum concentration employed (30 μM). The results show that vasorelaxation by 4-phenylquinazolin-2(1H)-one derivatives might depend on the activation of a signalling pathway triggered by endothelium-derived factors.

Production of quinazolinone compounds

2(1H)-Quinazolinone derivatives, which are useful as anti-inflammatory agents, are prepared by heating or hydrolyzing an acylurea derivative. The acylurea derivative can be prepared by either reacting an indole derivative with an oxidizing agent or reacti

Process for preparing quinazolines

Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.