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1H-Pyrazole,4-chloro-3-nitro-(9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

400752-98-9

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400752-98-9 Usage

Heterocyclic compound

5-membered aromatic ring with 2 nitrogen atoms and 1 chlorine atom

Nitro derivative

Contains one or more nitro groups (-NO2)

Building block

Potential use in the synthesis of pharmaceuticals and agrochemicals

Intermediate

Used in the production of various drugs, pesticides, and chemical products

Biological activities

Has potential biological activities, making it a subject of interest in pharmaceutical research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 400752-98-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,0,7,5 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 400752-98:
(8*4)+(7*0)+(6*0)+(5*7)+(4*5)+(3*2)+(2*9)+(1*8)=119
119 % 10 = 9
So 400752-98-9 is a valid CAS Registry Number.

400752-98-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloro-5-nitro-1H-pyrazole

1.2 Other means of identification

Product number -
Other names Pyrazole,4-chloro-3-nitro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:400752-98-9 SDS

400752-98-9Upstream product

400752-98-9Downstream Products

400752-98-9Relevant academic research and scientific papers

Design, Synthesis, and Biological Evaluation of 1-Benzyl-1H-pyrazole Derivatives as Receptor Interacting Protein 1 Kinase Inhibitors

Zou, Chan,Xiong, Yu,Huang, Lu-Yi,Song, Chun-Li,Wu, Xiao-Ai,Li, Lin-Li,Yang, Sheng-Yong

, p. 569 - 574 (2016)

Receptor interacting protein 1 (RIP1) kinase plays an important role in necroptosis, and inhibitors of the RIP1 kinase are thought to have a potential therapeutic value in the treatment of diseases related to necrosis. Herein, we report the structural optimization of a RIP1 kinase inhibitor, 1-(2,4-dichlorobenzyl)-3-nitro-1H-pyrazole (1a). A number of 1-benzyl-1H-pyrazole derivatives were synthesized and structure-activity relationship (SAR) analysis led to the discovery of a potent compound, 4b, which showed a Kd value of 0.078 μm against the RIP1 kinase and an EC50 value of 0.160 μm in a cell necroptosis inhibitory assay. Compound 4b also displayed considerable ability to protect the pancreas in an l-arginine-induced pancreatitis mouse model.

Benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives, and preparation method and application thereof

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Paragraph 0057; 0058; 0059; 0060, (2016/10/09)

The invention belongs to the field of chemical medicine, and particularly relates to benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives, and a preparation method and application thereof. The structure of the benzyl-1H-pyrazole and benzyl-1H-pyrazole de

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