400776-21-8 Usage
Structure
Thiazole derivative with a carboxylic acid functional group and a methoxyphenyl ether group
Usage
Often used in pharmacological research and drug development
Potential properties
May have antimicrobial, anti-inflammatory, or other pharmacological activities
Additional research
Necessary to fully understand its potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 400776-21-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,0,7,7 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 400776-21:
(8*4)+(7*0)+(6*0)+(5*7)+(4*7)+(3*6)+(2*2)+(1*1)=118
118 % 10 = 8
So 400776-21-8 is a valid CAS Registry Number.
400776-21-8Relevant articles and documents
A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors
Larsen, Scott D.,Stachew, Carl F.,Clare, Paula M.,Cubbage, Jerry W.,Leach, Karen L.
, p. 3491 - 3495 (2007/10/03)
Two-dimensional libraries of 4-acylamino-1,3-thiazoles 9 were prepared via Curtius rearrangement of 1,3-thiazole-4-carbonyl azides 6, trapping of the intermediate isocyanates with oxime resin, and thermal regeneration of the isocyanates from the washed resin in the presence of nucleophiles. Several compounds proved to be selective inhibitors of CDK5/p25 versus the closely homologous CDK2/cyclin A enzyme, with the best analogue (43) possessing over 100-fold selectivity.
