400777-00-6

Basic information

• Product Name: CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER
• Synonyms: CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER;-(6-chloro-4-iodo-3-pyridinyl)-, 1,1-diMethylethyl ester;tert-butyl 6-chloro-4-iodopyridin-3-ylcarbaMate;(6-Chloro-4-iodo-pyridin-3-yl)-carbaMic acid tert-butyl ester;Carbamic acid, N-(6-chloro-4-iodo-3-pyridinyl)-, 1,1-dimethylethyl ester
• CAS NO: 400777-00-6
• Molecular Formula: C₁₀H₁₂ClIN₂O₂
• Molecular Weight: 354.57
• Mol File: 400777-00-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 339.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.723±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.27±0.70(Predicted)
• CAS DataBase Reference: CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER(400777-00-6)
• EPA Substance Registry System: CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER(400777-00-6)

Safety Data

• Hazardous Substances Data: 400777-00-6(Hazardous Substances Data)

Usage

General Description

Carbamic Acid, (6-chloro-4-iodo-3-pyridinyl)-, 1,1-dimethylethyl ester is a specialized chemical compound with a distinct molecular structure. Specific elements in its structure include Carbon, Hydrogen, Nitrogen, Oxygen, Chlorine, Iodine, and the Pyridine group. This particular compound's attributes and properties may vary based on its structural setup but primarily it would possess the characteristics of the Carbamic acid group which includes a carbonyl (a carbon double bonded to an oxygen) and a single bonded NH2 group, and those of the 1,1-Dimethylethyl ester group such as being an ester of tertiary butanol, also known as tert-butanol. It is commonly used in the synthesis of other specific chemicals, pharmaceuticals, and potentially for research purposes. However, specific details about the compound's usage, hazardous risks, possible toxicity, and other information should be obtained from its designated Material Safety Data Sheet (MSDS).

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 109-72-8 n-butyllithium 
• 171178-45-3 tert-butyl (6-chloropyridin-3-yl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 

Downstream Products

• 825643-73-0 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide 
• 1072085-89-2 tert-butyl 6-chloro-4-(cyclobutylethynyl)pyridin-3-ylcarbamate 
• 400777-01-7 Methyl 5-Chloro-2-(4-chlorophenyl)-1H-pyrrolo [2,3-c]pyridine-3-propanoate 
• 400777-03-9 3-[5-chloro-2-(4-chloro-phenyl)-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-propionic acid methyl ester 
• 351227-42-4 6-chloro-4-iodopyridin-3-amine 

Relevant articles and documents

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator

Compounds and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor, based on 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)3yridine-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium and pharmaceutically acceptable salts thereof.

Carboxymethyl piperidine derivative

The present invention provides a novel compound useful in the prevention or treatment of nausea and vomiting associated with the administration of antineoplastics, the compound having an NK1 receptor-antagonizing effect, and an inhibitory effect on CYP3A4 that is attenuated to a greater extent than in aprepitant. Specifically, the present invention relates to a carboxymethyl piperidine derivative represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, ring A is a benzene ring or the like, ring B is a pyridine ring or the like, R1 is a C1-6 alkyl or C1-6 alkoxy, R2 and R3 are hydrogen atoms or methyl, and n represents an integer of from 0 to 5.