400878-24-2 Usage
Description
1-(2-[(4-Fluorobenzyl)oxy]phenyl)-1-ethanone, also known as 4'-fluoroacetophenone, is a chemical compound with the molecular formula C15H13FO2. It is a white solid with a molecular weight of 244.26 g/mol. 1-(2-[(4-FLUOROBENZYL)OXY]PHENYL)-1-ETHANONE is used in the synthesis of various pharmaceuticals and organic compounds and can also serve as a building block in the production of other chemicals. Due to its hazardous nature, it should be handled with care, following proper safety precautions and guidelines.
Uses
Used in Pharmaceutical Industry:
1-(2-[(4-Fluorobenzyl)oxy]phenyl)-1-ethanone is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medications.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 1-(2-[(4-Fluorobenzyl)oxy]phenyl)-1-ethanone is used as a building block for the synthesis of other organic compounds, facilitating the creation of a wide range of chemical products.
Used in Chemical Production:
1-(2-[(4-FLUOROBENZYL)OXY]PHENYL)-1-ETHANONE also plays a role in the production of other chemicals, where it serves as a key component in the manufacturing process, contributing to the final product's properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 400878-24-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,0,8,7 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 400878-24:
(8*4)+(7*0)+(6*0)+(5*8)+(4*7)+(3*8)+(2*2)+(1*4)=132
132 % 10 = 2
So 400878-24-2 is a valid CAS Registry Number.
400878-24-2Relevant articles and documents
Natural Products as Sources of New Fungicides (I): Synthesis and Antifungal Activity of Acetophenone Derivatives Against Phytopathogenic Fungi
Ma, Ya-Tuan,Fan, Hua-Fang,Gao, Yu-Qi,Li, He,Zhang, An-Ling,Gao, Jin-Ming
, p. 545 - 552 (2013/06/05)
Several series of 45 acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by 1H and 13C NMR spectroscopy, HRMS and single-crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate assay. Of them, 12 derivatives (e.g., 3a-c, 4c and 4e) exhibited more potent antifungal effects on some phytopathogens than a commercial fungicide hymexazol as positive control. In particular, compound 3b with IC50 values of 10-19μg/mL was found to be the most active in this series and might be a potential lead structure for further optimization. The preliminary structure-activity relationship (SAR) studies of a series of acetophenones are also discussed. A series of acetophenone derivatives have been synthesized and tested for their antifungal activities. Of them 12 derivatives exhibited more potent antifungal effects on some phytopathogens than a positive control hymexazol. Especially, compound 3b (IC50=10-19μg/mL) was found to be the most active and might be a potential lead structure. The SAR of these acetophenones is also discussed.
