40089-09-6

Upstream product

• 1195-32-0 1-methyl-4-isopropenylbenzene 

Downstream Products

• 109334-07-8 (3S,4S)-2,2-Dichloro-4-methyl-3-((1S,2R)-2-phenyl-cyclohexyloxy)-4-p-tolyl-cyclobutanone 
• 109334-06-7 1-Methyl-4-[(E)-1-methyl-2-((1S,2R)-2-phenyl-cyclohexyloxy)-vinyl]-benzene 
• 109334-08-9 (R)-2-Chloro-4-methyl-4-p-tolyl-cyclopent-2-enone 
• 109334-10-3 (4R)-3,4-dimethyl-4-(p-tolyl)-2-cyclopentenone 
• 28152-91-2 (R)-(+)-β-cuparenone 
• 109334-05-6 1-Methyl-4-[1-((1S,2R)-2-phenyl-cyclohexyloxymethyl)-vinyl]-benzene 

Relevant academic research and scientific papers

One-Pot Twofold Unsymmetrical C-Si Bond 2,6-Bifunctionalization of Arenes via Sequential [1,4]-Csp2 to O-Silyl Migration

Twofold unsymmetrical C-Si bond bifunctionalization of 2,6-di(trimethylsilyl) benzyl alcohols has been achieved in one pot via sequential [1,4]-Csp2 to O-silyl migration. The hydroxyl group functions as an "on-off-on" switch to control two successive silyl migrations, and 4,7-dimethyl-o-phenanthroline ligand favors cleavage of the endocyclic C-Si bond. Diverse Csp3/Csp3 or Csp2/Csp3 electrophiles can be installed at the 2- and 6-positions. This approach was used to chemoselectively functionalize the three C-Si bonds of 2,4,6-tri(trimethylsilyl) benzyl alcohol, transforming it into isochroman derivatives. The approach even works as a five-component reaction to construct complex symmetric structures.