4009-98-7Relevant articles and documents
A synthetic approach to 5/5/6-polycyclic tetramate macrolactams of the discodermide type
Bodenschatz, Kevin,St?ckl, Julia,Winterer, Markus,Schobert, Rainer
, (2021/05/31)
A flexible synthetic route to the 16-membered tetramate-embedding macrocyclic scaffold present in various polycyclic tetramate macrolactams (PTMs) was developed which differs from the seminal synthesis of ikarugamycin by Boeckman Jr. in protecting groups and the order of connections. We also devised a short approach to various stereoisomers of the 5/5/6-tricarbocyclic motif found in discodermide and other PTMs, starting from the Weiss’ diketone.
Preparation method of 2-cyclopropyl propanal
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Paragraph 0022; 0025, (2019/04/06)
The invention relates to the field of organic synthesis, in particular to a synthesis method of 2-cyclopropyl propanal. According to the method, methoxy methyl triphenyl phosphonium chloride is reacted with cyclopropyl methyl ketone under the action of a base to generate 1-methoxy-2-cyclopropyl propanal; and the 1-methoxy-2-cyclopropyl propanal undergoes acidification and hydrolysis form the 2-cyclopropyl propanal. The synthesized 2-cyclopropyl propanal is calculated by cyclopropyl methyl ketone, has a yield which is more than 95%, and has the advantages of being less in by-products, high in yield and low in cost.
A (methoxy methyl) trityl chloride synthesis method (by machine translation)
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Paragraph 0008; 0017; 0018; 0019; 0020; 0021; 0022-0025, (2017/08/28)
The invention relates to the field of chemical synthesis, in particular to a (methoxy methyl) trityl chloride synthesis method, comprises the following steps: under the protection of nitrogen, is added to the reactor solvent anhydrous acetone, then adding triphenylphosphine, to side edge which temperature rises to 36 - 38 °C, maintain a constant temperature, the methyl ether is added to the reactor, after the 36 - 38 °C lower reaction 3h, the temperature slowly increased to 46 - 48 °C, continue to reaction 3h, stopping the reaction, filtration, anhydrous ethyl ether washing, drying, to obtain (methoxy methyl) trityl chloride; this invention synthetic (a ethoxymethyl) trityl chloride high yield, purity is good, the synthetic method is simple, easy to control, is suitable for popularization and application. (by machine translation)