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4009-98-7

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4009-98-7 Usage

Chemical Properties

WHITE TO ALMOST WHITE FINE CRYSTALLINE POWDER

Uses

Different sources of media describe the Uses of 4009-98-7 differently. You can refer to the following data:
1. (Methoxymethyl)triphenylphosphonium chloride is used as a phase transfer catalyst and in the synthesis of taxol-A fragment. It is widely used in the synthesis of pharmaceutical product cephalotaxine, which is used as an antiviral and antitumor agent.
2. Intermediates of Liquid Crystals

Check Digit Verification of cas no

The CAS Registry Mumber 4009-98-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,0 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4009-98:
(6*4)+(5*0)+(4*0)+(3*9)+(2*9)+(1*8)=77
77 % 10 = 7
So 4009-98-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H20OP.ClH/c1-21-17-22(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20;/h2-16H,17H2,1H3;1H/q+1;/p-1

4009-98-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Packaging
  • Price
  • Detail
  • TCI America

  • (M0828)  (Methoxymethyl)triphenylphosphonium Chloride  >99.0%(HPLC)

  • 4009-98-7

  • 25g

  • 280.00CNY

  • Detail
  • TCI America

  • (M0828)  (Methoxymethyl)triphenylphosphonium Chloride  >99.0%(HPLC)

  • 4009-98-7

  • 100g

  • 790.00CNY

  • Detail
  • TCI America

  • (M0828)  (Methoxymethyl)triphenylphosphonium Chloride  >99.0%(HPLC)

  • 4009-98-7

  • 500g

  • 2,350.00CNY

  • Detail
  • Alfa Aesar

  • (A14380)  (Methoxymethyl)triphenylphosphonium chloride, 98+%   

  • 4009-98-7

  • 25g

  • 347.0CNY

  • Detail
  • Alfa Aesar

  • (A14380)  (Methoxymethyl)triphenylphosphonium chloride, 98+%   

  • 4009-98-7

  • 100g

  • 839.0CNY

  • Detail
  • Alfa Aesar

  • (A14380)  (Methoxymethyl)triphenylphosphonium chloride, 98+%   

  • 4009-98-7

  • 500g

  • 3177.0CNY

  • Detail
  • Aldrich

  • (309567)  (Methoxymethyl)triphenylphosphoniumchloride  97%

  • 4009-98-7

  • 309567-25G

  • 670.41CNY

  • Detail
  • Aldrich

  • (309567)  (Methoxymethyl)triphenylphosphoniumchloride  97%

  • 4009-98-7

  • 309567-100G

  • 1,633.32CNY

  • Detail

4009-98-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (Methoxymethyl)triphenylphosphonium chloride

1.2 Other means of identification

Product number -
Other names methoxymethyl(triphenyl)phosphanium,chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4009-98-7 SDS

4009-98-7Synthetic route

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

triphenylphosphine
603-35-0

triphenylphosphine

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

Conditions
ConditionsYield
In dichloromethane Reflux;100%
In toluene at 95℃; for 16h;97.3%
In neat (no solvent) at 80℃; for 4h; Solvent; Temperature; Time; Inert atmosphere; Schlenk technique;93%
Dimethoxymethane
109-87-5

Dimethoxymethane

triphenylphosphine
603-35-0

triphenylphosphine

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

Conditions
ConditionsYield
With acetyl chloride In methanol at 65℃; for 3h;94%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

3,4-dihydronaphthalene-1(2H)-one
529-34-0

3,4-dihydronaphthalene-1(2H)-one

1-[1-Methoxy-meth-(E)-ylidene]-1,2,3,4-tetrahydro-naphthalene

1-[1-Methoxy-meth-(E)-ylidene]-1,2,3,4-tetrahydro-naphthalene

Conditions
ConditionsYield
With sodium hexamethyldisilazane In 1,4-dioxane at 0℃; for 1h;100%
bis(p-methylphenyl)-methanone
611-97-2

bis(p-methylphenyl)-methanone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

4,4'-(2-methoxyethene-1,1-diyl)bis(methylbenzene)
528856-86-2

4,4'-(2-methoxyethene-1,1-diyl)bis(methylbenzene)

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran; 1,4-dioxane for 2h; Wittig olefination; Heating;100%
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one
1210-35-1

10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

5-methoxymethylene-10,11-dihydro-5H-dibenzo[a,d]cycloheptene

5-methoxymethylene-10,11-dihydro-5H-dibenzo[a,d]cycloheptene

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran; 1,4-dioxane for 2h; Wittig olefination; Heating;100%
3,3'-difluorobenzophenone
345-70-0

3,3'-difluorobenzophenone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C15H12F2O

C15H12F2O

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran; 1,4-dioxane for 2h; Wittig olefination; Heating;100%
2,2'-dichlorobenzophenone
5293-97-0

2,2'-dichlorobenzophenone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C15H12Cl2O

C15H12Cl2O

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran; 1,4-dioxane for 2h; Wittig olefination; Heating;100%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

4,4'-Difluorobenzophenone
345-92-6

4,4'-Difluorobenzophenone

1,1-bis(4-fluorophenyl)-2-methoxyethene
53780-24-8

1,1-bis(4-fluorophenyl)-2-methoxyethene

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran; 1,4-dioxane for 2h; Wittig olefination; Heating;100%
Stage #1: (methoxymethyl)triphenylphosphonium chloride With n-butyllithium In 1,4-dioxane; hexane at 0℃; Wittig reaction;
Stage #2: 4,4'-Difluorobenzophenone In 1,4-dioxane; hexane at 0℃; Wittig reaction; Reflux;
82%
2-iodoacetophenone
2142-70-3

2-iodoacetophenone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

2-(2-iodophenyl)-1-methoxypropene

2-(2-iodophenyl)-1-methoxypropene

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 25℃; for 0.5h;
Stage #2: 2-iodoacetophenone In tetrahydrofuran at 25℃; for 1h;
100%
2-iodobenzophenone
25187-00-2

2-iodobenzophenone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

1-(2-iodophenyl)-2-methoxy-1-phenylethene

1-(2-iodophenyl)-2-methoxy-1-phenylethene

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 25℃; for 0.5h;
Stage #2: 2-iodobenzophenone In tetrahydrofuran at 25℃; for 1h;
100%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

2-(naphthalen-2-yl)benzene-1,3-dicarbaldehyde
652976-99-3

2-(naphthalen-2-yl)benzene-1,3-dicarbaldehyde

2-[2,6-di(2-methoxyethenyl)phenyl]naphthalene

2-[2,6-di(2-methoxyethenyl)phenyl]naphthalene

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran; diethyl ether at -78 - 0℃; for 1h; Wittig reaction;
Stage #2: 2-(naphthalen-2-yl)benzene-1,3-dicarbaldehyde In tetrahydrofuran; diethyl ether at 20℃;
100%
3-(6-methoxy-1-naphthyl)thiophene-2-carboxaldehyde
842167-24-2

3-(6-methoxy-1-naphthyl)thiophene-2-carboxaldehyde

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

3-(6-methoxy-naphthalen-1-yl)-2-(2-methoxy-vinyl)-thiophene

3-(6-methoxy-naphthalen-1-yl)-2-(2-methoxy-vinyl)-thiophene

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h;
Stage #2: 3-(6-methoxy-1-naphthyl)thiophene-2-carboxaldehyde In tetrahydrofuran at 20℃; for 2h; Wittig reaction;
100%
4-dimethylamino-4-phenylcyclohexanone
65619-20-7

4-dimethylamino-4-phenylcyclohexanone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

4-(dimethylamino)-4-phenylcyclohexanecarbaldehyde
693260-35-4

4-(dimethylamino)-4-phenylcyclohexanecarbaldehyde

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 4-dimethylamino-4-phenylcyclohexanone In tetrahydrofuran at 20℃;
100%
Stage #1: 4-dimethylamino-4-phenylcyclohexanone; (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In toluene at 70℃; Wittig Reaction;
Stage #2: With water
Stage #1: 4-dimethylamino-4-phenylcyclohexanone; (methoxymethyl)triphenylphosphonium chloride With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 72h;
Stage #2: With hydrogenchloride; water In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran; dimethyl sulfoxide at 0℃; for 0.25h;
Stage #2: 4-dimethylamino-4-phenylcyclohexanone In tetrahydrofuran; dimethyl sulfoxide at 20℃;
Stage #3: With hydrogenchloride; sodium hydroxide; water more than 3 stages;
Stage #1: (methoxymethyl)triphenylphosphonium chloride With sodium hydride In DMF (N,N-dimethyl-formamide)
Stage #2: 4-dimethylamino-4-phenylcyclohexanone In DMF (N,N-dimethyl-formamide) at 20℃; for 72h;
Stage #3: With hydrogenchloride; sodium hydroxide; water more than 3 stages;
2,6-difluoro-4-(4-propylphenyl)benzaldehyde

2,6-difluoro-4-(4-propylphenyl)benzaldehyde

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C18H18F2O

C18H18F2O

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 1h;
Stage #2: 2,6-difluoro-4-(4-propylphenyl)benzaldehyde In tetrahydrofuran at 0 - 20℃; for 2h;
100%
4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one
863514-54-9

4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

4-dimethylamino-4-(3-fluorophenyl)-cyclohexane carbaldehyde
1189555-37-0

4-dimethylamino-4-(3-fluorophenyl)-cyclohexane carbaldehyde

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 0℃; Inert atmosphere;
Stage #2: 4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one In tetrahydrofuran at 20℃;
100%
Stage #1: (methoxymethyl)triphenylphosphonium chloride With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 20℃; for 2h; Inert atmosphere;
Stage #2: 4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere;
1-(3-methyl-4'-trifluoromethyl-biphenyl-4-yl)-ethanone
871250-23-6

1-(3-methyl-4'-trifluoromethyl-biphenyl-4-yl)-ethanone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

4-(2-methoxy-1-methyl-vinyl)-3-methyl-4'-trifluoromethyl-biphenyl
871250-27-0

4-(2-methoxy-1-methyl-vinyl)-3-methyl-4'-trifluoromethyl-biphenyl

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: 1-(3-methyl-4'-trifluoromethyl-biphenyl-4-yl)-ethanone In tetrahydrofuran at 20℃; for 2h;
100%
4-(2,3-difluoro-4-ethoxyphenyl)-cyclohexanone
220437-02-5

4-(2,3-difluoro-4-ethoxyphenyl)-cyclohexanone

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

1-ethoxy-2,3-difluoro-4-(4-(methoxymethylene)cyclohexyl)benzene
245530-35-2

1-ethoxy-2,3-difluoro-4-(4-(methoxymethylene)cyclohexyl)benzene

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran for 1h; Inert atmosphere; Cooling with ice;
Stage #2: 4-(2,3-difluoro-4-ethoxyphenyl)-cyclohexanone In tetrahydrofuran for 3h; Cooling with ice;
100%
Stage #1: (methoxymethyl)triphenylphosphonium chloride In tetrahydrofuran at -30 - -20℃; for 0.5h; Inert atmosphere;
Stage #2: 4-(2,3-difluoro-4-ethoxyphenyl)-cyclohexanone In tetrahydrofuran at -30 - -20℃; for 0.5h; Inert atmosphere;
65%
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at -30 - -20℃; Inert atmosphere;
Stage #2: 4-(2,3-difluoro-4-ethoxyphenyl)-cyclohexanone In tetrahydrofuran at -30 - -10℃;
With potassium tert-butylate In tetrahydrofuran; water
With potassium tert-butylate In tetrahydrofuran at -10℃; for 2h; Temperature; Wittig Olefination; Inert atmosphere;45.2 g
3,4-dimethoxy-(phenylmethoxy)benzaldehyde
6527-13-5

3,4-dimethoxy-(phenylmethoxy)benzaldehyde

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

2-(benzyloxy)-3,4-dimethoxy-1-(2-methoxyvinyl)benzene

2-(benzyloxy)-3,4-dimethoxy-1-(2-methoxyvinyl)benzene

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: 3,4-dimethoxy-(phenylmethoxy)benzaldehyde In tetrahydrofuran at 20℃; for 14h; Wittig reaction; Inert atmosphere;
100%
C21H26O2Si

C21H26O2Si

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C23H30O2Si

C23H30O2Si

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: C21H26O2Si In tetrahydrofuran for 1.5h; Inert atmosphere;
100%
2,3-difluoro-4'-propylbiphenyl-4-carbaldehyde
126163-03-9

2,3-difluoro-4'-propylbiphenyl-4-carbaldehyde

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C18H18F2O

C18H18F2O

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at -30℃; for 0.5h; Inert atmosphere;
Stage #2: 2,3-difluoro-4'-propylbiphenyl-4-carbaldehyde In tetrahydrofuran for 8h; Inert atmosphere;
100%
C22H38O2

C22H38O2

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C24H42O2

C24H42O2

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -30℃; Inert atmosphere;100%
C20H21FO2

C20H21FO2

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C22H25FO2

C22H25FO2

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at -30℃; for 1h; Inert atmosphere;
Stage #2: C20H21FO2 In tetrahydrofuran at 20℃; for 3h;
100%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C23H15NO

C23H15NO

C25H19NO

C25H19NO

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran for 2h;100%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C20H22O

C20H22O

C22H26O

C22H26O

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 0 - 10℃; for 2h; Inert atmosphere;
Stage #2: C20H22O In tetrahydrofuran at 0 - 10℃; for 1h; Inert atmosphere;
100%
1-benzyl-2,2,6,6-tetramethylpiperidine-4-one
52981-86-9

1-benzyl-2,2,6,6-tetramethylpiperidine-4-one

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

4-(methoxymethylene)-2,2,6,6-tetramethylpiperidine
56061-90-6

4-(methoxymethylene)-2,2,6,6-tetramethylpiperidine

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 0℃; for 1h;
Stage #2: N-benzyl-2,2,6,6-tetramethyl-piperidin-4-one In tetrahydrofuran at 5℃; for 2h;
99.9%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

2-bromo-6-hydroxy-4-methylbenzaldehyde
133129-29-0

2-bromo-6-hydroxy-4-methylbenzaldehyde

2-bromo-6-methoxy-4-methylphenylacetaldehyde
630120-19-3

2-bromo-6-methoxy-4-methylphenylacetaldehyde

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium hexamethylsilazane In toluene for 1h;
Stage #2: 2-bromo-6-methoxy-4-methylbenzaldehyde In toluene at 20℃; for 2h; Wittig reaction;
Stage #3: With hydrogenchloride In acetone for 3.5h; Heating;
99%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal
92817-88-4

(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

tert-Butyl-((E)-(R)-4-methoxy-2-methyl-but-3-enyloxy)-diphenyl-silane
339533-81-2

tert-Butyl-((E)-(R)-4-methoxy-2-methyl-but-3-enyloxy)-diphenyl-silane

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: (2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal In tetrahydrofuran at 0℃; for 1.5h; Further stages.;
99%
(S,E)-2-(4-methoxybenzyloxy)-2-methyl-8-((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)oct-5-enal
931113-57-4

(S,E)-2-(4-methoxybenzyloxy)-2-methyl-8-((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)oct-5-enal

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C25H38O5
931113-81-4

C25H38O5

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: (S,E)-2-(4-methoxybenzyloxy)-2-methyl-8-((S)-2,2,4-trimethyl-1,3-dioxolan-4-yl)oct-5-enal In tetrahydrofuran at -78℃; for 1h; Wittig olefination; Further stages.;
99%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

(1R,4aR,8R,8aS,10aS)-1,4a,8-Trimethyl-8-vinyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carbaldehyde
467222-29-3

(1R,4aR,8R,8aS,10aS)-1,4a,8-Trimethyl-8-vinyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carbaldehyde

C22H34O

C22H34O

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran for 0.5h; Wittig Reaction;99%
2-(4-bromonaphthalen-1-yl)benzaldehyde
1155911-73-1

2-(4-bromonaphthalen-1-yl)benzaldehyde

(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

1-bromo-4-[1-(2-methoxyvinyl)phenyl]naphthalene
1155911-74-2

1-bromo-4-[1-(2-methoxyvinyl)phenyl]naphthalene

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;99%
With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;99%
With potassium tert-butylate In tetrahydrofuran at 25℃; for 2h; Inert atmosphere;99%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

2-(4-methylpiperazin-1-yl)benzaldehyde
85803-62-9

2-(4-methylpiperazin-1-yl)benzaldehyde

[2-(4-methylpiperazin-1-yl)phenyl]acetaldehyde
886593-59-5

[2-(4-methylpiperazin-1-yl)phenyl]acetaldehyde

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With potassium tert-butylate In tetrahydrofuran at 10℃; for 0.25h;
Stage #2: 2-(4-methylpiperazin-1-yl)benzaldehyde In tetrahydrofuran at 20℃;
Stage #3: With hydrogenchloride; potassium carbonate more than 3 stages;
99%

4009-98-7Relevant articles and documents

A synthetic approach to 5/5/6-polycyclic tetramate macrolactams of the discodermide type

Bodenschatz, Kevin,St?ckl, Julia,Winterer, Markus,Schobert, Rainer

, (2021/05/31)

A flexible synthetic route to the 16-membered tetramate-embedding macrocyclic scaffold present in various polycyclic tetramate macrolactams (PTMs) was developed which differs from the seminal synthesis of ikarugamycin by Boeckman Jr. in protecting groups and the order of connections. We also devised a short approach to various stereoisomers of the 5/5/6-tricarbocyclic motif found in discodermide and other PTMs, starting from the Weiss’ diketone.

Preparation method of 2-cyclopropyl propanal

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Paragraph 0022; 0025, (2019/04/06)

The invention relates to the field of organic synthesis, in particular to a synthesis method of 2-cyclopropyl propanal. According to the method, methoxy methyl triphenyl phosphonium chloride is reacted with cyclopropyl methyl ketone under the action of a base to generate 1-methoxy-2-cyclopropyl propanal; and the 1-methoxy-2-cyclopropyl propanal undergoes acidification and hydrolysis form the 2-cyclopropyl propanal. The synthesized 2-cyclopropyl propanal is calculated by cyclopropyl methyl ketone, has a yield which is more than 95%, and has the advantages of being less in by-products, high in yield and low in cost.

A (methoxy methyl) trityl chloride synthesis method (by machine translation)

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Paragraph 0008; 0017; 0018; 0019; 0020; 0021; 0022-0025, (2017/08/28)

The invention relates to the field of chemical synthesis, in particular to a (methoxy methyl) trityl chloride synthesis method, comprises the following steps: under the protection of nitrogen, is added to the reactor solvent anhydrous acetone, then adding triphenylphosphine, to side edge which temperature rises to 36 - 38 °C, maintain a constant temperature, the methyl ether is added to the reactor, after the 36 - 38 °C lower reaction 3h, the temperature slowly increased to 46 - 48 °C, continue to reaction 3h, stopping the reaction, filtration, anhydrous ethyl ether washing, drying, to obtain (methoxy methyl) trityl chloride; this invention synthetic (a ethoxymethyl) trityl chloride high yield, purity is good, the synthetic method is simple, easy to control, is suitable for popularization and application. (by machine translation)

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