40100-63-8

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-bromophenoxy)propan-2-one is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications. Its unique structure allows for further chemical reactions and modifications, making it a valuable component in the creation of a wide range of therapeutic compounds.
Used in Organic Chemistry:
As a common reagent in organic chemistry, 1-(2-bromophenoxy)propan-2-one is utilized in numerous organic reactions, facilitating the synthesis of a diverse array of organic compounds.
Used in Agrochemical Synthesis:
1-(2-bromophenoxy)propan-2-one is also employed as an intermediate in the synthesis of agrochemicals, playing a role in the development of products that protect crops and enhance agricultural productivity.
Used in Specialty Chemicals:
1-(2-bromophenoxy)propan-2-one finds application in the synthesis of specialty chemicals, which are tailored for specific industries and applications, showcasing the versatility of 1-(2-bromophenoxy)propan-2-one in various sectors.

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 598-31-2 1-bromoacetone 
• 78-95-5 chloroacetone 
• 1666-18-8 4-Chlor-benzolsulfonsaeure-acetolester 

Downstream Products

• 923594-98-3 2-(2-bromophenoxymethyl)-2-methyl-1,3-dioxolane 
• 1036762-65-8 C₁₀H₁₁BrN₂O 
• 444605-03-2 1-(2-bromophenoxy)propan-2-amine 
• 444605-14-5 N-[1-(2-bromophenoxy)propan-2-yl]-acetamide 
• 923595-04-4 2-(2-oxopropoxy)phenylboronic acid 

Relevant academic research and scientific papers

Stereoselective Access to 1-[2-Bromo(het)aryloxy]propan-2-amines Using Transaminases and Lipases; Development of a Chemoenzymatic Strategy Toward a Levofloxacin Precursor

Two independent enzymatic strategies have been developed toward the synthesis of enantioenriched 1-[2-bromo(het)aryloxy]propan-2-amines. With that purpose a series of racemic amines and prochiral ketones have been synthesized from commercially available 2-bromophenols or brominated pyridine derivatives bearing different pattern substitutions in the aromatic ring. Biotransamination experiments have been studied using ketones as starting materials, yielding both the (R)- and (S)-amine enantiomers with high selectivity (91-99% ee) depending on the transaminase source. In a complementary approach, the classical kinetic resolutions of the racemic amines have been investigated using Candida antarctica lipase type B as biocatalyst. Ethyl methoxyacetate was found as a suitable acyl donor leading to the corresponding (S)-amines (90-99% ee) and (R)-amides (88-99% ee) with high selectivity in most of the cases. A preparative biotransamination process has been developed for the synthesis of (2S)-1-(6-bromo-2,3-difluorophenoxy)propan-2-amine in 61% isolated yield after 24 h, a valuable precursor of the antimicrobial agent Levofloxacin.

Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds

A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.

Cationic palladium complex catalyzed highly enantioselective intramolecular addition of arylboronic acids to ketones. A convenient synthesis of optically active cycloalkanols

An efficient and convenient synthesis of optically active cycloalkanols by utilizing the chiral cationic palladium complex as the catalyst was achieved in mild conditions with high yield and high enantioselectivity. Copyright