40106-59-0

Basic information

• Product Name: 4-HYDRAZINO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[4,5]THIENO[2,3-D]PYRIMIDINE
• Synonyms: 4-HYDRAZINO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[4,5]THIENO[2,3-D]PYRIMIDINE;5H-CYCLOHEPTA[4,5]THIENO[2,3-D]PYRIMIDINE, 4-HYDRAZINO-6,7,8,9-TETRAHYDRO-;(6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]azulen-4-yl)-hydrazine
• CAS NO: 40106-59-0
• Molecular Formula: C11H14N4S
• Molecular Weight: 234.32
• Mol File: 40106-59-0.mol

Chemical Properties

• Boiling Point: 480.8°C at 760 mmHg
• Flash Point: 244.6°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 2.1E-09mmHg at 25°C
• Refractive Index: 1.736
• CAS DataBase Reference: 4-HYDRAZINO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[4,5]THIENO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDRAZINO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[4,5]THIENO[2,3-D]PYRIMIDINE(40106-59-0)
• EPA Substance Registry System: 4-HYDRAZINO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[4,5]THIENO[2,3-D]PYRIMIDINE(40106-59-0)

Safety Data

• Hazardous Substances Data: 40106-59-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14N4S/c12-15-10-9-7-4-2-1-3-5-8(7)16-11(9)14-6-13-10/h6H,1-5,12H2,(H,13,14,15)

Upstream product

• 502-42-1 cycloheptanone 
• 40106-13-6 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid ethyl ester 
• 40106-12-5 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide 
• 40106-31-8 6,7,8,96,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4(3H)-one-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 23917-22-8 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile 
• 40106-58-9 4-chloro-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3- d]pyrimidine 
• 483282-75-3 2-ethoxymethyleneamino-3-cyanocyclohepta(b)thiophene 

Downstream Products

• 380907-31-3 1-(3,5-dimethyl-1H-pyrazol-1-yl)cyclohepta(b)thieno[2,3-d]pyrimidine 

Relevant articles and documents

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors

Novel cycloalkene-fused thienopyrimidine analogues with enhanced phosphodiesterase 5 (PDE5) inhibitory properties are presented. The structure of the reported scaffold was modulated through variation of the terminal cycloalkene ring size, as well as by va

Design, Synthesis, and Biological Evaluation of Some Cyclohepta[b]Thiophene and Substituted Pentahydrocycloheptathieno[2,3-d]Pyrimidine Derivatives

This investigation describes the design of a series of cycloheptathieno[2,3-d]pyrimidines along with their synthetic strategy. The target compounds were screened for their PARP-1 inhibitory activity. The modeling study declared that most of the docked compounds showed the same interactions as 3-aminobenzamide, where Gly 894, His 862, Tyr 896, Arg 878, and Ser 864 were the main residues involved in hydrogen bond formation. Compounds eliciting the top ranked docking results were screened for their PARP-1 inhibitory activity giving promising results, and three representative compounds were tested for their cytotoxic activity using Doxorubicin as a reference standard. The target compounds 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 including cyclohepta[b]thiophene and pentahydrocycloheptathieno[2,3-d]pyrimidine cores were designed, prepared, and tested for their PARP-1 inhibitory activity. Compounds 16 (R: ―NHC(S)NH2) and 11 (R: ―C S) were the most potent ones.

Studies with polyfunctionality substituted heterocycles: Novel syntheses of thienopyrimido-1,2,4-triazoles

Several 3-substituted-(un)-cyclohepta(b)thieno[2,3-d]pyrimido[3,4-a]-1,2,4-triazoles 10, 11, 12, 13, and 14 were prepared by reaction of an appropriate substituted 2-amino-3-cyanothiophene 1 with aliphatic acids or benzoyl chloride. Also the fusion of 1 with urea, thiourea to give the corresponding 2-oxo or thioxo-4-aminopyrimidine derivatives 6a, b and other reactions of compound 1 are reported.