40116-78-7

Upstream product

• 779-53-3 4-morpholinylacetophenone 
• 110-91-8 morpholine 
• 20780-53-4 (R)-Styrene oxide 
• 40434-87-5 (R)-2-hydroxy-2-phenylethyl 4-methylbenzenesulfonate 
• 16355-00-3 (R)-1-phenyl-1,2-ethanediol 
• 4432-34-2 2-morpholino-1-phenylethanol 
• 93-56-1 phenylethane 1,2-diol 
• 70-11-1 α-bromoacetophenone 

Relevant academic research and scientific papers

Synthesis of chiral alcohols by asymmetric reductions of various ketones including α-aminophenones

LiAlH4 previously treated with 2.5 equiv. of (S)-(+) or (R)-(-)-2-(2-isoindolinyl)butan-1-ol 1 reduced the six α-aminophenones 4-9 into the corresponding optically active β-aminoalcohols 10-15 whose ee's were in the range of 40-97% after chroma

Acid-Assisted Ru-Catalyzed Enantioselective Amination of 1,2-Diols through Borrowing Hydrogen

Here, we present a highly enantioselective synthesis of 1,2-amino alcohols from readily available racemic 1,2-diols through a borrowing hydrogen process. An intriguing acid effect was discovered for this Ru-catalyzed amination reaction, which led to a sig

AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS

The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Ruthenium-catalyzed enantioselective synthesis of β-amino alcohols from 1,2-diols by "borrowing hydrogen"

Enantioselective synthesis of β-amino alcohols from 1,2-diols by the use of [RuCl2(p-cymene)]2/(S,R)-JOSIPHOS catalysis was developed. Several 1,2-diols were treated with secondary amines to afford the corresponding optically active

Boranes in Synthesis. 6. A New Synthesis of β-Amino Alcohols from Epoxides. Use of Lithium Amides and Aminoborane Catalysts To Synthesize β-Amino Alcohols from Terminal and Internal Epoxides in High Yield

A study of the conversion of terminal and internal epoxides to the corresponding β-amino alcohols using simple primary and secondary lithium amides has been carried out.Thus, styrene oxide and 1,2-epoxydodecane react directly with primary and secondary lithium amides in THF at 25 deg C to give a single regioisomer of the corresponding β-amino alcohols in 80-100percent isolated yields.Since internal epoxides are known to yield predominantly allylic alcohols when reacted with lithium amides, we employed a series of aminoborane Lewis-acid catalists, generated in situ, to suppress formation of the allylic alcohols.Thus, the reaction of cyclohexene oxide with a variety of primary and secondary lithium amides at 34 deg C in diethyl ether in the presence of a catalytic amount of B-bromo-9-BBN afforded the corresponding β-amino alcohols in 70-95percent isolated yield.

Boranes in Synthesis. 2. Asymmetric Synthesis of β-Amino Alcohols. A Facile Conversion of 2-Amino Acetophenones to the Corresponding β-Amino Alcohols in High Enantiomeric Purity

The asymmetric reduction of 2-amino acetophenones with Ipc2BH or Ipc2BCl at -78 deg C, yields the corresponding β-amino alcohols in good to excellent yields.Although only modest (12-45percent ee) enantiomeric excesses were obtained with Ipc2BH, 75-99perce

Asymmetric Synthesis. Part 6. Asymmetric Reduction of Aminoketones with (-)-Bornan-2-exo-yloxyaluminium Dichloride

α-Dialkylaminoacetophenones and β-dialkylaminopropiophenones have been reduced asymmetrically with (-)-bornan-2-exo-yloxyaluminium dichloride to the corresponding aminoalcohols in 58-92percent enantiomeric excess.The absolute configurations of the predomi