10-Hydroxydesipramine is a derivative of the compound Desipramine (CAS#50-47-5), which is a potent tricyclic antidepressant. It possesses a hydroxyl group at the 10th position, enhancing its pharmacological properties. This modification allows 10-hydroxydesipramine to exhibit improved efficacy in treating depressive disorders by selectively inhibiting the norepinephrine transporter, thereby increasing the availability of norepinephrine in the synaptic cleft.
4014-82-8
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Basic information
- Product Name: 10-hydroxydesipramine
- Synonyms: 10-hydroxydesipramine
- CAS NO:4014-82-8
- Molecular Formula: C18H22N2O
- Molecular Weight: 282.38008
- EINECS: N/A
- Product Categories: N/A
- Mol File: 4014-82-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 439°C at 760 mmHg
- Flash Point: 219.3°C
- Appearance: /
- Density: 1.123g/cm3
- Vapor Pressure: 1.75E-08mmHg at 25°C
- Refractive Index: 1.598
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 10-hydroxydesipramine(CAS DataBase Reference)
- NIST Chemistry Reference: 10-hydroxydesipramine(4014-82-8)
- EPA Substance Registry System: 10-hydroxydesipramine(4014-82-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 4014-82-8(Hazardous Substances Data)
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4014-82-8 Usage
Uses
Used in Pharmaceutical Industry:10-Hydroxydesipramine is used as an antidepressant for the treatment of major depressive disorder and other mood-related conditions. Its application is based on its ability to selectively inhibit the norepinephrine transporter, leading to an increase in norepinephrine levels in the brain, which is associated with improved mood and reduced depressive symptoms.
Additionally, due to its structural similarity to Desipramine, 10-hydroxydesipramine may also be used in research and development for the creation of novel antidepressant drugs with potentially better efficacy, fewer side effects, or improved pharmacokinetic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 4014-82-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,1 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.Calculate Digit Verification of CAS Registry Number 4014-82:
(6*4)+(5*0)+(4*1)+(3*4)+(2*8)+(1*2)=58
58 % 10 = 8
So 4014-82-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H22N2O/c1-19-11-6-12-20-16-9-4-2-7-14(16)13-18(21)15-8-3-5-10-17(15)20/h2-5,7-10,18-19,21H,6,11-13H2,1H3
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10-hydroxydesipramine
