40143-47-3

Upstream product

• 98143-91-0 2-((benzyloxy)imino)-2-phenylacetamide 
• 1670-14-0 benzamidine monohydrochloride 
• 501-53-1 benzyl chloroformate 
• 100-44-7 benzyl chloride 

Downstream Products

• 31492-52-1 3-benzyloxy-5-hydroxy-2-phenyl-3H-pyrano[2,3-d]pyrimidine-4,7-dione 
• 40143-40-6 C₃₁H₂₈N₄O₄ 
• 1359955-84-2 1-benzyl 5-ethyl 2-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1359955-74-0 1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate 
• 1359955-68-2 1-benzyloxycarbonyl-4-dimethylamino-2-phenyl-1,3-diaza-1,3-butadiene 
• 1022-44-2 4-amino-2-phenyl-quinazoline 

Relevant academic research and scientific papers

Construction of dihydropyrimidine skeleton using 1,2,4-trisubstituted-1,3- diaza-1,3-butadienes

Construction of a dihydropyrimidine ring was developed that involved the cyclization of 1,3-diaza-1,3-butadienes having an N-protecting group (N-Cbz, N-Boc, N-alkyl, or N-benzyl) with α,β-unsaturated carbonyl compounds such as ethyl acrylate and p-chlorophenyl vinyl ketone. Consequently, 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidines were synthesized in good yields. Subsequently, the β-elimination of the dimethylamino group was carried out with MeI or SiO2 to afford various N-protecting-2,5- disubstituted-1,6-dihydropyrimidines in good yields. Remarkably, the use of 4-chlorophenyl vinyl ketone directly provided the dihydropyrimidine without the tetrahydropyrimidine intermediate in excellent yield.