401468-50-6

Basic information

• Product Name: Benzenepropanoic acid, b-hydroxy-a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester
• CAS NO: 401468-50-6
• Molecular Formula: C25H26O5
• Molecular Weight: 406.478
• Mol File: 401468-50-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-hydroxy-a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-hydroxy-a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester(401468-50-6)
• EPA Substance Registry System: Benzenepropanoic acid, b-hydroxy-a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester(401468-50-6)

Safety Data

• Hazardous Substances Data: 401468-50-6(Hazardous Substances Data)

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 42412-84-0 ethyl 2-phenoxypropionate 

Downstream Products

• 223126-68-9 2-phenoxy-3-(4-benzyloxyphenyl)-2-methylpropionic acid ethyl ester 
• 401791-04-6 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester 
• 401790-98-5 (R)-2-methyl-3{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester 
• 401790-99-6 (S)-2-methyl-3{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester 
• 401790-97-4 2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-2-phenoxy-propionic acid ethyl ester 
• 853260-14-7 3-{4-[2-(2-biphenyl-3-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy-propionic acid ethyl ester 
• 698347-45-4 3-{4-[2-(2-biphenyl-4-yl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-methyl-2-phenoxypropionic acid ethyl ester 
• 401468-49-3 3-{4-[2-(2-Biphenyl-4-yl-5-methyloxazol-4-yl)ethoxy]-phenyl}-2-methyl-2-phenoxypropionic acid 
• 401790-93-0 (R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester 
• 401790-95-2 (S)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester 
• 401790-94-1 3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy-propionic Acid Ethyl Ester 
• 401789-88-6 (S)-3-{4-[2-(2-Phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy propionic acid 
• 401468-52-8 (S)-(-)-3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester 
• 401468-51-7 (R)-(+)-3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester 

Relevant articles and documents

PYRIMIDINYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS

The present invention disclosed compounds of Structural Formula (I), and enantiomer, racemic body, pharmaceutically acceptable salts, solvates or hydrates thereof, wherein variable groups are as defined within, as well as methods for preparing such compou

Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes

PPARγ and 11β-HSD1 are attractive therapeutic targets for type 2 diabetes. However, PPARγ agonists induce adipogenesis, which causes the side effect of weight gain, whereas 11β-HSD1 inhibitors prevent adipogenesis and may be beneficial for the treatment of obesity in diabetic patients. For the first time, we designed, synthesized a series of α-aryloxy-α-methylhydrocinnamic acids as dual functional agents which activate PPARγ and inhibit 11β-HSD1 simultaneously. The compound 11e exhibited the most potent inhibitory activity compared to that of the lead compound 2, with PPARγ (EC50 = 6.76 μM) and 11β-HSD1 (IC50 = 0.76 μM) in vitro. Molecular modeling study for compound 11e was also presented. Compound 11e showed excellent efficacy for lowering glucose, triglycerides, body fat, in well established mice and rats models of diabetes and obesity and had a favorable ADME profile.

Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/ γ Agonists

The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist (S)-2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl} -2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated d