401515-26-2Relevant academic research and scientific papers
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase
Chamorro, Cristina,Lobaton, Esther,Bonache, Maria-Cruz,De Clercq, Erik,Balzarini, Jan,Velazquez, Sonsoles,San-Felix, Ana,Camarasa, Maria-Jose
, p. 3085 - 3088 (2007/10/03)
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.
