401518-40-9Relevant academic research and scientific papers
Highly potent PDE4 inhibitors with therapeutic potential
Ochiai, Hiroshi,Ohtani, Tazumi,Ishida, Akiharu,Kusumi, Kensuke,Kato, Masashi,Kohno, Hiroshi,Odagaki, Yoshihiko,Kishikawa, Katuya,Yamamoto, Susumu,Takeda, Hiroshi,Obata, Takaaki,Nakai, Hisao,Toda, Masaaki
, p. 4645 - 4665 (2007/10/03)
Synthesis and biological evaluation of piperidine derivatives is reported. The hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system prompted us to design and synthesize a hydrophilic piperidine
Highly potent PDE4 inhibitors with therapeutic potential
Ochiai, Hiroshi,Ohtani, Tazumi,Ishida, Akiharu,Kusumi, Kensuke,Kato, Masashi,Kohno, Hiroshi,Kishikawa, Katuya,Obata, Takaaki,Nakai, Hisao,Toda, Masaaki
, p. 207 - 210 (2007/10/03)
Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of
Piperidine derivatives and drugs containing these derivatives as active ingredient
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Page/Page column 20, (2008/06/13)
Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is useful for preventing and/or treating inflamm
