40154-00-5

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 92508-62-8 ethyl 2-(1-hydroxy-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetate 

Downstream Products

• 58491-25-1 6-methoxy-1,2,3,4-tetrahydro-1-naphthyl-acetic acid ethyl ester 
• 805248-48-0 {6-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-1,2,3,4-tetrahydronaphthalen-1-yl}acetic acid 
• 805248-47-9 C₂₉H₃₂O₃ 

Relevant academic research and scientific papers

Construction of functionalized indans by thallium(III) promoted ring contraction of 3-alkenols

An efficient four step protocol for the construction of functionalized indans was developed. 1-Tetralones were transformed into unsaturated esters by Reformatsky reaction with bromo-esters (ethyl 2-bromopropionate, ethyl bromoacetate or ethyl 2-bromobutyrate), followed by dehydration of the β-hydroxy-ester formed. Reduction of the ester moiety led to homoallylic alcohols bearing an endocyclic double bond. The oxidative rearrangement of these 3-alkenols was performed by thallium trinitrate (TTN) in a 2:1 mixture of AcOH/H2O, leading to the ring contraction products in moderate to very good yield. Fourteen examples of this sequence were studied. The oxidation of 3-alkenols prepared from 2-tetralones with TTN was also investigated. With these substrates the ring contraction reaction was not observed.

Synthesis of novel molecular probes inspired by harringtonolide

A novel harringtonolide-inspired scaffold containing a cycloheptatriene ring and two fused cyclopentane rings has been synthesised from simple starting materials. The scaffold, containing a similar substitution pattern and relative stereochemistry to the