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401567-04-2

3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-chlorobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 401567-04-2 Structure

  • Basic information

    1. Product Name: 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-chlorobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine
    2. Synonyms: 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-chlorobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine
    3. CAS NO:401567-04-2
    4. Molecular Formula:
    5. Molecular Weight: 555.101
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 401567-04-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-chlorobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-chlorobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine(401567-04-2)
    11. EPA Substance Registry System: 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-chlorobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine(401567-04-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 401567-04-2(Hazardous Substances Data)

401567-04-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 401567-04-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,1,5,6 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 401567-04:
(8*4)+(7*0)+(6*1)+(5*5)+(4*6)+(3*7)+(2*0)+(1*4)=112
112 % 10 = 2
So 401567-04-2 is a valid CAS Registry Number.

401567-04-2Downstream Products

401567-04-2Relevant articles and documents

Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group

Yoshida, Tomohiro,Akahoshi, Fumihiko,Sakashita, Hiroshi,Sonda, Shuji,Takeuchi, Masahiro,Tanaka, Yoshihito,Nabeno, Mika,Kishida, Hiroyuki,Miyaguchi, Ikuko,Hayashi, Yoshiharu

, p. 5033 - 5041 (2012/09/22)

Hypoglycemic agents with a mechanism of depeptidyl peptidase IV (DPP-4) inhibition are suitable for once daily oral dosing. It is difficult to strike a balance between inhibitory activity and duration of action in plasma for inhibitors bearing an electrophilic nitrile group. We explored fused bicyclic heteroarylpiperazine substituted at the γ-position of the proline structure in the investigation of l-prolylthiazolidines lacking the electrophilic nitrile. Among them, 2-trifluoroquinolyl compound 8g is the most potent, long-lasting DPP-4 inhibitor (IC50 = 0.37 nmol/L) with high selectivity against other related peptidases. X-ray crystal structure determination of 8g indicates that CH-π interactions generated between the quinolyl ring and the guanidinyl group of Arg358 enhances the DPP-4 inhibitory activity and selectivity.

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