401575-24-4

Usage

Uses

Used in Organic Synthesis:
2,2,2-Trifluoro-N-(2-pyridylMethyl)acetaMide, 96% is used as a building block for the synthesis of complex organic molecules due to its unique properties and reactivity.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,2,2-Trifluoro-N-(2-pyridylMethyl)acetaMide, 96% is used as a key intermediate in the development of new drugs, contributing to the advancement of medicinal chemistry.

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1128191-95-6 C₆H₈N₂*C₇H₈O₃S 
• 120221-68-3 3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-carboxylic acid 

Relevant academic research and scientific papers

Distorted Copper(II) Complex with Unusually Short CF···Cu Distances

We find a Cu(II)-(L-CF3)2 complex (L-CF3 = 2,2,2-trifluoro-N-[2-(pyridin-2-yl)propan-2-yl]acetamide) with a distorted seesaw geometry. It has the shortest crystallographic CF···Cu distances yet reported, to the best of our knowledge (?), for which computational and experimental data indicate a secondary bonding interaction. A comparison with a CCl3 version and one without ligand backbone gem-dimethyl groups suggests a steric origin for the distorted geometry, resulting from the specific ligand interactions.

meta-Selective C?H Borylation of Benzylamine-, Phenethylamine-, and Phenylpropylamine-Derived Amides Enabled by a Single Anionic Ligand

Selective functionalization at the meta position of arenes remains a significant challenge. In this work, we demonstrate that a single anionic bipyridine ligand bearing a remote sulfonate group enables selective iridium-catalyzed borylation of a range of common amine-containing aromatic molecules at the arene meta position. We propose that this selectivity is the result of a key hydrogen bonding interaction between the substrate and catalyst. The scope of this meta-selective borylation is demonstrated on amides derived from benzylamines, phenethylamines and phenylpropylamines; amine-containing building blocks of great utility in many applications.

Efficient Preparation of Imidazo[1,5- a ]pyridine-1-carboxylic Acids

We report a novel and efficient approach to the synthesis of imidazo[1,5-a]pyridine-1-carboxylic acids. By using the reaction of 2-(aminomethyl)pyridine with acyl chlorides followed by one-pot treatment with trifluoroacetic anhydride, 2,2,2-trifluoro-1-im