401593-01-9Relevant academic research and scientific papers
Synthesis of a hexasaccharide that relates to the arabinogalactan epitope
Gu, Guofeng,Yang, Feng,Du, Yuguo,Kong, Fanzuo
, p. 99 - 106 (2007/10/03)
A hexasaccharide derivative of the arabinogalactan epitope, methyl β-D-galactopyranosyl-(1 → 6)-[α-L-arabinofuranosyl-(1 → 3)]-β-D-galactopyranosyl-(1 → 6)-β-D-galactopyranosyl-(1 → 6)-[α-L-arabinofuranosyl-(1 → 3)]-α-D-galactopyranoside, was synthesized efficiently using a 3 + 3 strategy. The key step is the preparation of the trisaccharide donor, isopropyl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1 → 6)-[2,3,5-tri-O-benzoyl-α-L-arabinofuranosyl-(1 → 3)]-2,4-di-O-benzoyl-1-thio-β-D-galactopyranoside, from isopropyl 1-thio-β-D-galactopyranoside using a one-pot synthesis of a 3,6-differentially protected building block.
A simple access to 3,6-branched oligosaccharides: Synthesis of a glycopeptide derivative that relates to Lycium barbarum L.
Du, Yuguo,Zhang, Meimei,Yang, Feng,Gu, Guofeng
, p. 3122 - 3127 (2007/10/03)
An efficient method is described for the synthesis of galactopyranosyl-containing 3,6-branched oligosaccharides using isopropyl thiogalactopyranoside as starting material. This method is successfully applied to the preparation of a glycopeptide derivative that relates to Lycium barbarum L. The potential application of isopropyl thioglycoside in glycosylation is also investigated.
