4016-01-7

Basic information

• Product Name: 2-hydroxy-3-methylbenzenesulphonic acid
• Synonyms: 2-hydroxy-3-methylbenzenesulphonic acid;3-Methyl-2-hydroxybenzenesulfonic acid;o-Cresol-6-sulfonic acid;Einecs 223-670-8
• CAS NO: 4016-01-7
• Molecular Formula: C₇H₈O₄S
• Molecular Weight: 188.20102
• EINECS: 223-670-8
• Mol File: 4016-01-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.482g/cm³
• Refractive Index: 1.597
• CAS DataBase Reference: 2-hydroxy-3-methylbenzenesulphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-methylbenzenesulphonic acid(4016-01-7)
• EPA Substance Registry System: 2-hydroxy-3-methylbenzenesulphonic acid(4016-01-7)

Safety Data

• Hazardous Substances Data: 4016-01-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8O4S/c1-5-3-2-4-6(7(5)8)12(9,10)11/h2-4,8H,1H3,(H,9,10,11)

Upstream product

• 95-48-7 ortho-cresol 

Downstream Products

• 534-52-1 6-methyl-2,4-dinitrophenol 

Relevant articles and documents

Process for aryl-quinone and aryl-naphthoquinone diazide sulfonic acids

A process for the preparation of aryl-diazide-sulfonic acids by a series of sequential in-situ process steps. The process comprises the nitrosation of a hydroxyarylsulfonic acid; conversion of the nitroso-derivative to a sulfamate which is then diazotized to the diazide. Temperature and pH are maintained in predetermined ranges to maintain the reaction products in solution without the formation side-products or the need to isolate intermediates. The process of the invention is particularly useful in the preparation of light-sensitive materials such as naphthoquinonediazide sulfonic acids which are used in the preparation of photoresist compositions. The invention provides a high purity product at a high material efficiency, high equipment utilization, low effluent discharge, and reduced cost.

Aromatic Sulphonation. Part 91. The Sulphonation of Anisole, Phenol, Phenyl Methanesulphonate, Potassium Phenyl Sulphate, and a Series of Methyl-, Bromo-, and Chloro-substituted Anisoles and Phenols in Concentrated Aqueous Sulphuric Acid

The (homogeneous) sulphonation of a number of aromatic ethers and alcohols, viz. anisole (1), 3-methyl- (2), 4-methyl- (3), 2-bromo- (4), 4-bromo- (5), 2-chloro- (6), and 4-chloro-anisole (7), phenol (8), 2-methyl- (9), 3-methyl- (10), 4-methyl- (11), 4-bromo- (12), 2-chloro- (13), and 4-chloro-phenol (14), phenyl methanesulphonate (15), and potassium phenyl sulphate (16) in concentrated aqueous sulphuric acid at 25.0 deg C has been studied, and rates and isomer distributions have been determined.The sulphonation is first-order in the aromatic substrate, and from the rate measurements it is concluded that the species undergoing sulphonation in the phenyl ring is an unprotonated substrate species.In the lower acid concentrations the sulphonating entity is H3SO4(1+).With increasing sulphuric acid concentration there is a gradual change-over in the sulphonating entity from H3SO4(1+) to H2S2O7.The acid concentrations of equal rate contribution by the two entities for anisole and phenol are 87 and 90 +/- 1percent, respectively.Sulphonation on the oxygen atom (i.e., sulphation) does not occur.The o/p-ratios for (1) and (8) do not vary over the studied sulphuric acid range of 75-90percent H2SO4.Partial rate factors for the 2- and 4-position of (1) and (8) are reported.The very low partial rate factors for the 4-substitution of (1) and (8) and the observed extreme suppression and compression of the reactivities of the substrates (1)-(14) are ascribed to hydrogen bonding of the substrates with the acidic solvent species present.It is tentatively suggested that the relatively high contents of sulphonation ortho to -OR with anisole (36percent) and phenol (48percent) are due to specific complexation of the substrates with the sulphonating electrophile.