401604-21-5

Upstream product

• 6326-83-6 bis(carboxymethyl)trithiocarbonate 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 1329121-23-4 (Z)-4-(5-(2-(5-methoxy-1H-indol-3-yl)-2-oxoethylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzonitrile 
• 1329121-24-5 (Z)-4-(5-(2-(1H-indol-3-yl)-2-oxoethylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzonitrile 

Relevant academic research and scientific papers

An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4- one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indol-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxothiazolidine-4-ones were prepared from the corresponding aromatic amines (1a-e) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acid chlorides (5a-d) using HSnBu 3.

Methods of Making and Using Thioxothiazolidine and Rhodanine Derivatives as HIV-1 and JSP-1 Inhibitors

The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having HIV-1 or JSP-1 inhibitory activity.