401620-95-9

Basic information

• Product Name: 3-Oxa-5,8,14-triazahexadecan-16-oic acid, 2,2-dimethyl-6-[2-(methylthio)ethyl]-4,7,13-trioxo-15-(phenylmethyl)-, methyl ester, (6S,15S)-
• CAS NO: 401620-95-9
• Molecular Formula: C25H39N3O6S
• Molecular Weight: 509.667
• Mol File: 401620-95-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Oxa-5,8,14-triazahexadecan-16-oic acid, 2,2-dimethyl-6-[2-(methylthio)ethyl]-4,7,13-trioxo-15-(phenylmethyl)-, methyl ester, (6S,15S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxa-5,8,14-triazahexadecan-16-oic acid, 2,2-dimethyl-6-[2-(methylthio)ethyl]-4,7,13-trioxo-15-(phenylmethyl)-, methyl ester, (6S,15S)-(401620-95-9)
• EPA Substance Registry System: 3-Oxa-5,8,14-triazahexadecan-16-oic acid, 2,2-dimethyl-6-[2-(methylthio)ethyl]-4,7,13-trioxo-15-(phenylmethyl)-, methyl ester, (6S,15S)-(401620-95-9)

Safety Data

• Hazardous Substances Data: 401620-95-9(Hazardous Substances Data)

Upstream product

• 401620-92-6 2-(5-tert-butoxycarbonylamino-pentanoylamino)-3-phenyl-propionic acid methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 27219-07-4 5-(N-tert-butyloxycarbonyl)aminopentanoic acid 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 

Relevant articles and documents

Synthesis and activity on human neutrophil functions of fMLF-OMe analogs containing alkyl spacers at the central position.

We report here the synthesis and activity of new analogs of the N-formyl and N-tert-butyloxycarbonyl (Boc) derivatives of the tripeptide Met-Leu-Phe-OMe containing an achiral omega-amino acid residue replacing the hydrophobic central leucine. The tripeptides HCO-Met-NH-(CH2)n-CO-Phe-OMe and Boc-Met-NH-(CH2)n-CO-Phe-OMe (n = 3-5) containing the central homomorphic residue of 5-aminopentanoic acid (delta-aminovaleric acid; delta-Ava; n = 4) and the two non-homomorphic residues of 4-aminobutanoic acid (gamma-aminobutyric acid; gamma-Abu; n = 3) and 6-aminohexanoic acid (epsilon-aminocaproic acid; epsilon-Aca; n = 5) have been examined. The activity as agonists and antagonists in chemotaxis, lysozyme release, and superoxide anion production of the new analogs has been determined. The N-Boc derivatives 2a and 2b, incorporating the gamma-Abu and the delta-Ava residues, show good and selective antagonist activity on superoxide anion production.