40163-27-7

Upstream product

• 43083-10-9 4-ethyl-1,6,7,8-tetrahydro-10H-pyrano[3,4-f]indolizine-3,10(4H)-dione 
• 40163-24-4 5,6-dibromo-4-ethyl-1,6,7,8-tetrahydro-4H-pyrano[3,4-f]indolizine-3,10-dione 
• 43083-06-3 2-(6-acetoxymethyl-1,8-dibromo-5-oxo-1,2,3,5-tetrahydro-indolizin-7-yl)-butyric acid methyl ester 

Relevant academic research and scientific papers

Preparation method of tricyclic lactone through C20 site hydroxylation

The invention discloses a preparation method of tricyclic lactone through C20 site hydroxylation, and belongs to the technical field of organic synthesis. In the presence of an organic amine (such asN-methylmorpholine, N-methylpiperidine, 2, 2, 6, 6-tetramethylpiperidine), an oxidant (such as air) and an inorganic base (such as cesium carbonate or potassium carbonate), a raw material I reacts inan organic solvent to obtain a 20-site oriented oxidation product II. The directional oxidation method is efficient, clean and high in yield, and the obtained directional 20 hydroxyl product can be split through enzyme splitting or chiral auxiliaries or form an epimer to be separated to obtain a single chiral isomer product.