401647-49-2Relevant articles and documents
Mild oxidation of tosylmethylisocyanide to tosylmethylisocyanate: Utility in synthetic and medicinal chemistry
Le, Hoang V.,Ganem, Bruce
supporting information, p. 2003 - 2005 (2014/04/03)
A convenient and efficient (one-step) oxidation is reported of commercially available tosylmethylisocyanide (TOSMIC) to form tosylmethylisocyanate, making this highly reactive bifunctional molecule a readily available synthetic reagent. Besides engaging in nucleophilic addition reactions with alcohols, amines, and thiols, tosylmethylisocyanate also reacts with carboxylic acids to form tosylmethylamides, which undergo substitution reactions in the presence of organocopper and organomagnesium reagents.
