40169-97-9Relevant academic research and scientific papers
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.
Cannon,Jackson,Long,Leonard,Bhatnagar
, p. 1959 - 1962 (2007/10/02)
Prompted by previous findings that a p-dimethoxy substitution pattern on an aromatic ring permits retention of dopaminergic agonist effects in certain ring systems, catechol derivatives of which are potent dopaminergic agonists, an 8,11-dimethoxy substitu
3-O-(1-PHENYLTETRAZOL-5-YL)MORPHINE IN THE ACID-CATALYZED MORPHINE-APOMORPHINE REARRANGEMENT: FORMATION OF A SIDE PRODUCT DUE TO 1-PHENYLTETRAZOLE GROUP MIGRATION
Mohan, Prem,Cannon, Joseph G.
, p. 1817 - 1820 (2007/10/02)
Acid catalyzed rearrangement of the title compound leads to a second aporphine derivative in addition to the expected product, 10-O-(1-phenyltetrazol-5-yl)-apomorphine.This side product is isomeric with the expected product, and it was shown to be 11-O-(1-phenyltetrazol-5-yl)apomorphine, apparently formed by tetrazole ring migration in the course of the acid catalyzed rearrangement of the morphine derivative.
(R)-(-)-10-Methyl-11-hydroxyaporphine: A Highly Selective Serotonergic Agonist
Cannon, Joseph G.,Mohan, Prem,Bojarski, Jacek,Long, John Paul,Bhatnagar, Ranbir K.,et al.
, p. 313 - 318 (2007/10/02)
Prior work in these laboratories identified (+/-)-5-hydroxy-6-methyl-2-(di-n-propylamino)tetralin as a dopaminergic agonist prodrug.The ortho methyl hydroxy aromatic substitution pattern in this molecule has now been incorporated into the aporphine ring s
