40180-82-3

Upstream product

• 40180-81-2 2-(3-bromo-4-methylphenyl)propan-2-ol 
• 2437-76-5 2-bromo-p-cymene 
• 1389311-90-3 C₁₀H₁₂BrCl 
• 104901-43-1 methyl 3-bromo-4-methylbenzoate 
• 40180-80-1 3-bromo-4-methylacetophenone 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 1637571-01-7 C₂₂H₃₄O₄Si 
• 1637571-03-9 C₁₀H₁₃BrO 
• 1637571-02-8 C₁₆H₂₇BrOSi 

Relevant academic research and scientific papers

CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS

This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-y which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Total synthesis of mansonone e

The synthesis of mansonone E was completed in six steps and 34% overall yield from commercially available starting material 3-bromo-4-methyl acetophenone. The thermal ring expansion of a cyclobutenedione derivative followed by an intramolecular 1,3-alkoxy exchange provided a facile route to the 1,2-naphthoquinone tricyclic structure of mansonone E.

Solvolysis of 2-chloro-2(3,4-disubstituted) phenylpropanes: Validity of Hammett-Brown σ+ constants in assessing additive effects of substituents

The objective of this study is to test the suitability of the extended Hammett-Brown equation, log (kXX/kHH) = ρ+∑σ+, in depicting satisfactorily additive effects of electronegative atom-bearing substituents, which are known to possess diverse and multicomponent influences on the side chain reactions of polysubstituted benzenes. The equation has been used to correlate, for the first time, the additive effect of substituents in the specific rates of solvolysis of 2-chloro-2-phenylpropanes (3b-3f) having 3-F,4-Me, 3-Br,4-Me, 3-I,4-Me, 3-Me,4-Me, or 3-MeO,4-Me substituents. The rates were determined titrimetrically at 288, 298, and 308 K using 90% aqueous acetone as solvent. Measured additive effects of these substituents on the solvolysis rate and activation parameters of the parent cumyl chloride (2-chloro-2-phenylpropane) are found to be well correlated using the equation given above. Plots of log (kXX/k HH) of 3b-3f together with mainly di-, but also tri- and mono-substituted cumyl chlorides from previous studies against ∑σ+ give a linear correlation coefficient of 0.990 as a measure of the validity of the equation to depict such systems. The halogen substituents' extent of conformity with additivity reflected in their relative (kobsd/kcalcd) rate ratios is found to correlate with the steric size of substituents. Plots of rate ratios against Taft's steric factor of each halogen give a linear correlation coefficient of 0.994 for the 3-halo substituents. The 3,4-dimethyl substituents' relative rate ratio of 1.03 shows excellent additivity, whereas the 3-methoxy-4-methyl ratio of 1.43 shows the methoxy group to be far less deactivating than predicted. Similar trends were found for the free energy of activation (δG? - δG 0?) differences, which correlated linearly with a coefficient of 0.983 with Taft's steric factor of halogen atoms.