401815-63-2Relevant academic research and scientific papers
Palladium-Catalyzed Regioselective Arylation of Pyrazolo[1,5-a]pyridines via C-H Activation and Synthetic Applications on P38 Kinase Inhibitors
Wu, Hung-Chou,Chu, Jean-Ho,Li, Chin-Wei,Hwang, Long-Chih,Wu, Ming-Jung
, p. 288 - 300 (2016)
A direct arylation of pyrazolo[1,5-a]pyridines with aryl iodides selectively occurring at the C-3 and C-7 positions via palladium-catalyzed C-H activation is described. In these reactions, (a) cesium(I) fluoride and (b) silver(I) carbonate were employed a
Au(i)-catalyzed and iodine-mediated cyclization of enynylpyrazoles to provide pyrazolo[1,5-a]pyridines
Wu, Hung-Chou,Yang, Chia-Wen,Hwang, Long-Chih,Wu, Ming-Jung
, p. 6640 - 6648 (2012/09/22)
Pyrazolo[1,5-a]pyridines and 6-iodopyrazolo[1,5-a]pyridines were synthesized by gold-catalyzed and iodine-mediated cyclization of enynylpyrazoles in good to excellent yields, respectively. The iodinated adducts were further converted to 6-arylpyrazolo[1,5
The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors
Cheung, Mui,Harris, Philip A.,Badiang, Jennifer G.,Peckham, Gregory E.,Chamberlain, Stanley D.,Alberti, Michael J.,Jung, David K.,Harris, Stephanie S.,Bramson, Neal H.,Epperly, Andrea H.,Stimpson, Stephen A.,Peel, Michael R.
scheme or table, p. 5428 - 5430 (2009/06/18)
A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
Fused pyrazole derivatives bieng protein kinase inhibitors
-
, (2008/06/13)
Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.
