401818-57-3Relevant academic research and scientific papers
2-Substituted estradiol bis-sulfamates, multitargeted antitumor agents: Synthesis, in vitro SAR, protein crystallography, and in vivo activity
Leese, Mathew P.,Leblond, Bertrand,Smith, Andrew,Newman, Simon P.,Di Fiore, Anna,De Simone, Giuseppina,Supuran, Claudiu T.,Purohit, Atul,Reed, Michael J.,Potter, Barry V. L.
, p. 7683 - 7696 (2007/10/03)
The anticancer activities and SARs of estradiol-17-O-sulfamates and estradiol 3,17-O,O-bis-sulfamates (E2bisMATEs) as steroid sulfatase (STS) inhibitors and antiproliferative agents are discussed. Estradiol 3,17-O,O-bis-sulfamates 20 and 21, in contrast t
