401834-33-1Relevant academic research and scientific papers
Regioselective ortho-hydroxylation of 2-arylbenzothiazole via substrate directed C-H activation
Banerjee, Arghya,Bera, Anupam,Guin, Srimanta,Rout, Saroj Kumar,Patel, Bhisma K.
, p. 2175 - 2183 (2013/03/14)
An efficient protocol has been developed for the direct ortho-hydroxylation of 2-arylbenzothiazole using Pd(OAc)2 as the catalyst and either of DIB/AcOH or Oxone/TFA combinations under air atmosphere. Under both these conditions, the methodology tolerates a diverse array of substituents giving good to excellent yields of corresponding ortho-hydroxylated products. Regioselective hydroxylation is observed at the less sterically hindered site of the phenyl ring possessing substituents at its meta position.
