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40188-45-2

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40188-45-2 Usage

Uses

Acebutolol (A123800)

Check Digit Verification of cas no

The CAS Registry Mumber 40188-45-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,1,8 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 40188-45:
(7*4)+(6*0)+(5*1)+(4*8)+(3*8)+(2*4)+(1*5)=102
102 % 10 = 2
So 40188-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO3/c1-3-4-12(16)13-9-5-6-11(15)10(7-9)8(2)14/h5-7,15H,3-4H2,1-2H3,(H,13,16)

40188-45-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A18672)  N-(3-Acetyl-4-hydroxyphenyl)butyramide, 97%   

  • 40188-45-2

  • 50g

  • 242.0CNY

  • Detail
  • Alfa Aesar

  • (A18672)  N-(3-Acetyl-4-hydroxyphenyl)butyramide, 97%   

  • 40188-45-2

  • 250g

  • 972.0CNY

  • Detail
  • Alfa Aesar

  • (A18672)  N-(3-Acetyl-4-hydroxyphenyl)butyramide, 97%   

  • 40188-45-2

  • 1000g

  • 3403.0CNY

  • Detail
  • Sigma-Aldrich

  • (Y0000127)  AcebutololimpurityC  European Pharmacopoeia (EP) Reference Standard

  • 40188-45-2

  • Y0000127

  • 1,880.19CNY

  • Detail
  • USP

  • (1000612)  AcebutololRelatedCompoundA  United States Pharmacopeia (USP) Reference Standard

  • 40188-45-2

  • 1000612-20MG

  • 14,578.20CNY

  • Detail

40188-45-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Acetyl-4-butyramidophenol

1.2 Other means of identification

Product number -
Other names 2-Acetyl-4-Butyramidephenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40188-45-2 SDS

40188-45-2Relevant articles and documents

Beta receptor blocker Acebutolol intermediate synthesized by photochemical Fries rearrangement

-

Paragraph 0025; 0027-0028; 0030-0031; 0033-0034; 0036..., (2021/10/27)

The invention belongs to the field of organic photochemistry and medicinal chemistry, and particularly relates to a beta receptor blocker Acebutolol intermediate synthesized by photochemical Fries rearrangement. An efficient continuous acetylation synthesis method is adopted, raw materials including p-aminophenol and n-butyric anhydride are mixed and subjected to a water diversion reaction with a water-carrying agent, then the water-carrying agent is removed through distillation, reactants are cooled, water is added as a dispersing agent, then liquid caustic soda is added for a reaction, phenate is generated, acetic anhydride is dropwise added, the mixture is stirred for a reaction, ester is generated, recrystallizing is carried out to generate a first-step product N-(4-acetoxyphenyl) butyrylamide; and in the step 2 photochemical Fries liquid phase rearrangement reaction is adopted, the product in the first step is dissolved in an organic solvent, then Fries rearrangement is carried out by irradiation of ultraviolet-visible light with a specific wavelength, the solvent is heated and evaporated after the reaction is completed, and the important intermediate 2-acetyl-4-n-butyryl aminophenol of Acebutolol is obtained after recrystallization. The method is simple and easy to implement, and low-toxicity, efficient and cheap green chemical reagents are used in the synthesis process.

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