401909-16-8

Basic information

• Product Name: N-(4-Cyano-2-fluorophenyl)MethanesulfonaMide
• Synonyms: N-(4-Cyano-2-fluorophenyl)MethanesulfonaMide;Methanesulfonamide, N-(4-cyano-2-fluorophenyl)-
• CAS NO: 401909-16-8
• Molecular Formula: C₈H₇FN₂O₂S
• Molecular Weight: 214.2167832
• Mol File: 401909-16-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 347.6°C at 760 mmHg
• Flash Point: 164°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 5.33E-05mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(4-Cyano-2-fluorophenyl)MethanesulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Cyano-2-fluorophenyl)MethanesulfonaMide(401909-16-8)
• EPA Substance Registry System: N-(4-Cyano-2-fluorophenyl)MethanesulfonaMide(401909-16-8)

Safety Data

• Hazardous Substances Data: 401909-16-8(Hazardous Substances Data)

Usage

General Description

N-(4-Cyano-2-fluorophenyl)MethanesulfonaMide is a chemical compound with the molecular formula C9H8FNO2S. It is a member of the sulfonylurea class of compounds, which are widely used as herbicides and pesticides. This specific compound has been studied for its potential use as a bioactive chemical in pharmaceutical research. It has also been investigated for its potential to inhibit the growth of cancer cells and as a potential therapeutic agent for certain types of cancer. The compound's chemical structure contains a cyano group, a fluorophenyl group, and a methanesulfonamide group, giving it potential chemical reactivity and biological activity. However, further research is needed to fully understand and harness its potential applications.

InChI:InChI=1/C8H7FN2O2S/c1-14(12,13)11-8-3-2-6(5-10)4-7(8)9/h2-4,11H,1H3

Upstream product

• 557-21-1 zinc(II) cyanide 
• 143937-74-0 2-fluoro-4-iodo-1-methanesulfonylaminobenzene 
• 29632-74-4 2-fluro-4-iodoaniline 
• 557-21-1 dicyanozinc 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 565448-36-4 N-(4-(aminomethyl)-2-fluorophenyl)methanesulfonamide 
• 921195-64-4 3-fluoro-4-(methanosulfonylamino)benzyl ammonium acetate 

Relevant articles and documents

Effect of TRPV1 Antagonist SC0030, a Potent Painkiller, on RANKL-mediated Osteoclast Differentiation Involved in Bone Resorption

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Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands

The chiral isomers of the two potent simplified RTX-based vanilloids, compounds 2 and 3, were synthesized employing highly enantioselective PTC alkylation and evaluated as hTRPV1 ligands. The analysis indicated that the R-isomer was the eutomer in binding affinity and functional activity. The agonism of compound 2R was comparable to that of RTX. Docking analysis of the chiral isomers of 3 suggested the basis for its stereospecific activity and the binding mode of 3R.

Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands

The chiral isomers of the two potent simplified RTX-based vanilloids, compounds 2 and 3, were synthesized employing highly enantioselective PTC alkylation and evaluated as hTRPV1 ligands. The analysis indicated that the R-isomer was the eutomer in binding affinity and functional activity. The agonism of compound 2R was comparable to that of RTX. Docking analysis of the chiral isomers of 3 suggested the basis for its stereospecific activity and the binding mode of 3R.