401935-11-3

Upstream product

• 61252-00-4 4-amino-β-oxobenzenepropanoic acid ethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1159790-23-4 7-methoxy-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-31-4 7-hydroxy-6-methoxy-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-17-6 6,8-dibromo-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-20-1 6, 8-di-tert-butyl-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-12-1 6-fluoro-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-27-8 7-diethylamino-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-33-6 6,7-dimethoxy-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-10-9 3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-15-4 6-chloro-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-16-5 6-bromo-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 
• 1159790-25-6 7-hydroxy-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 

Relevant academic research and scientific papers

Synthesis and evaluation of the α-glucosidase inhibitory activity of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives

In the course of studies directed toward the discovery of novel non-sugar α-glucosidase inhibitors for the treatment of diabetes, a series of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives was synthesized and evaluated as α-glucosidase inhibitors. Most compounds showed good inhibitory activity with IC50 values ranging from 0.0645?μM to 26.746?μM. 7-Hydroxy-6-methoxy-3-[4-(4-methylphenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one 7u manifested the most potent inhibitory activity with an IC50 value of 0.0645 μM.