40197-20-4

Usage

Uses

Used in Scientific Research:
5-Bromo-1H-benzoimidazole-2-carboxylic acid is used as a reagent in scientific research for the synthesis of more complex molecules. Its unique structure, which includes a bromo group, an imidazole ring, and a carboxylic acid group, makes it a valuable component in the development of new chemical compounds and materials.
Used in Pharmaceutical Industry:
5-Bromo-1H-benzoimidazole-2-carboxylic acid is used as a building block in the pharmaceutical industry for the development of new drugs. Its chemical properties and reactivity can be harnessed to create novel drug candidates with potential therapeutic applications.
Used in Chemical Synthesis:
5-Bromo-1H-benzoimidazole-2-carboxylic acid is used as an intermediate in chemical synthesis processes. Its versatility in forming various chemical bonds and its reactivity with other compounds make it a useful component in the production of a wide range of chemical products.
Used in Material Science:
5-Bromo-1H-benzoimidazole-2-carboxylic acid is used in material science research to develop new materials with unique properties. Its incorporation into polymers, for example, could potentially lead to the creation of materials with enhanced mechanical, thermal, or electrical properties.
Used in Analytical Chemistry:
5-Bromo-1H-benzoimidazole-2-carboxylic acid is used as a reference compound or standard in analytical chemistry for the calibration of instruments and the development of analytical methods. Its distinct chemical properties can be used to validate the accuracy and precision of analytical techniques.

InChI:InChI=1/C8H5BrN2O2/c9-4-1-2-5-6(3-4)11-7(10-5)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 540516-28-7 (5-bromo-1H-benzo[d]imidazol-2-yl)methanol 

Relevant academic research and scientific papers

Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents

A library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depended on the substituents attached to the bicyclic heterocycle. In particular, some compounds displayed antibacterial activity against two methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) comparable to the widely-used drug ciprofloxacin. The compounds have some common features; three possess 5-halo substituents; two are derivatives of (S)-2-ethanaminebenzimidazole; and the others are derivatives of one 2-(chloromethyl)-1Hbenzo[ d]imidazole and (1H-benzo[d]imidazol-2-yl)methanethiol. The results from the antifungal screening were also very interesting: 23 compounds exhibited potent fungicidal activity against the selected fungal strains. They displayed equivalent or greater potency in their MIC values than amphotericin B. The 5-halobenzimidazole derivatives could be considered promising broad-spectrum antimicrobial candidates that deserve further study for potential therapeutic applications.

CARBAMATE COMPOUND OR SALT THEREOF

[Problems] A compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases is provided. [Means for Solution] The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that a piperazine-1-carboxylate compound, in which benzimidazol-2-ylcarbonyl, benzofuran-2-ylcarbonyl or the like binds to the 4-position of the piperazine, has an excellent FAAH inhibitory activity and further has an action to increase the effective bladder capacity, an action to ameliorate sleep disorders, an anti-diuretic action, and an analgesic activity on lower urinary tract pain including bladder pain and the like, thereby completed the present invention. The carbamate compound of the present invention has an excellent FAAH inhibitory activity and can be used as an agent for preventing and/or treating FAAH-related diseases, particularly nocturia, interstitial cystitis, painful bladder syndrome, or chronic non-bacterial prostatitis/chronic pelvic pain syndrome.