402-37-9

Basic information

• Product Name: Ethanol, 2-[[3-(trifluoromethyl)phenyl]amino]-
• CAS NO: 402-37-9
• Molecular Formula: C9H10F3NO
• Molecular Weight: 205.18
• Mol File: 402-37-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[[3-(trifluoromethyl)phenyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[[3-(trifluoromethyl)phenyl]amino]-(402-37-9)
• EPA Substance Registry System: Ethanol, 2-[[3-(trifluoromethyl)phenyl]amino]-(402-37-9)

Safety Data

• Hazardous Substances Data: 402-37-9(Hazardous Substances Data)

Upstream product

• 75-21-8 oxirane 
• 98-16-8 3-trifluoromethylaniline 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 141-43-5 ethanolamine 
• 107-21-1 ethylene glycol 

Downstream Products

• 59085-34-6 2-phenyl-3-(3-trifluoromethyl-phenyl)-[1,3,2]oxazaphospholidine 
• 34889-58-2 4-(3-trifluoromethyl-phenyl)-morpholine-2,3-dione 
• 159177-81-8 N-(2-bromoethyl)-α,α,αtrifluoro-m-toluidine 
• 34889-60-6 2-methyl-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 34889-63-9 2-(4-methoxy-phenyl)-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 34889-62-8 2-phenyl-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 34889-61-7 2-heptyl-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 34889-59-3 3-(3-trifluoromethyl-phenyl)-oxazolidine 

Relevant articles and documents

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

Bacterial resistance to antibiotics makes previously manageable infections again disabling and lethal, highlighting the need for new antibacterial strategies. In this regard, inhibition of the bacterial division process by targeting key protein FtsZ has been recognized as an attractive approach for discovering new antibiotics. Binding of small molecules to the cleft between the N-terminal guanosine triphosphate (GTP)-binding and the C-terminal subdomains allosterically impairs the FtsZ function, eventually inhibiting bacterial division. Nonetheless, the lack of appropriate chemical tools to develop a binding screen against this site has hampered the discovery of FtsZ antibacterial inhibitors. Herein, we describe the first competitive binding assay to identify FtsZ allosteric ligands interacting with the interdomain cleft, based on the use of specific high-affinity fluorescent probes. This novel assay, together with phenotypic profiling and X-ray crystallographic insights, enables the identification and characterization of FtsZ inhibitors of bacterial division aiming at the discovery of more effective antibacterials.

Lewis acids catalyzed ring-opening reactions of methylenecyclopropanes and epoxides in supercritical carbon dioxide or modified supercritical carbon dioxide with perfluorocarbon

The reactions of methylenecyclopropanes (MCPs) and epoxides with alcohols and aromatic amines can be carried out in supercritical carbon dioxide (scCO2) or modified scCO2 with perfluorocarbon which offer a way to synthesize various alcohols, amino-alcohols, homoallylic ethers, and amines under an environmentally benign condition.