402-37-9

Upstream product

• 401-81-0 m-trifluoromethylphenyl iodide 
• 141-43-5 ethanolamine 
• 98-16-8 3-trifluoromethylaniline 
• 107-21-1 ethylene glycol 
• 75-21-8 oxirane 

Downstream Products

• 34889-62-8 2-phenyl-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 59085-34-6 2-phenyl-3-(3-trifluoromethyl-phenyl)-[1,3,2]oxazaphospholidine 
• 34889-61-7 2-heptyl-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 159177-81-8 N-(2-bromoethyl)-α,α,αtrifluoro-m-toluidine 
• 34889-58-2 4-(3-trifluoromethyl-phenyl)-morpholine-2,3-dione 
• 34889-60-6 2-methyl-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 34889-63-9 2-(4-methoxy-phenyl)-3-(3-trifluoromethyl-phenyl)-oxazolidine 
• 34889-59-3 3-(3-trifluoromethyl-phenyl)-oxazolidine 

Relevant academic research and scientific papers

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

Bacterial resistance to antibiotics makes previously manageable infections again disabling and lethal, highlighting the need for new antibacterial strategies. In this regard, inhibition of the bacterial division process by targeting key protein FtsZ has been recognized as an attractive approach for discovering new antibiotics. Binding of small molecules to the cleft between the N-terminal guanosine triphosphate (GTP)-binding and the C-terminal subdomains allosterically impairs the FtsZ function, eventually inhibiting bacterial division. Nonetheless, the lack of appropriate chemical tools to develop a binding screen against this site has hampered the discovery of FtsZ antibacterial inhibitors. Herein, we describe the first competitive binding assay to identify FtsZ allosteric ligands interacting with the interdomain cleft, based on the use of specific high-affinity fluorescent probes. This novel assay, together with phenotypic profiling and X-ray crystallographic insights, enables the identification and characterization of FtsZ inhibitors of bacterial division aiming at the discovery of more effective antibacterials.

β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction

Borrowing Hydrogen (BH), also called Hydrogen Autotransfer (HA), reaction with neat ethylene glycol represents a key step in the preparation of β-amino alcohols. However, due to the stability of ethylene glycol, mono-activation has rarely been achieved. Herein, a combination of Pd/C and ZnO is reported as heterogeneous catalyst for this BH/HA reaction. This system results in an extremely air and moisture stable, and economic catalyst able to mono-functionalize ethylene glycol in water, without further activation of the diol. In this work, different diols and aromatic amines have been explored affording a new approach towards amino alcohols. This study reveals how the combination of two solid species can afford interesting catalytic properties in heterogeneous phase. ZnO activates ethylene glycol while Pd/C is the responsible of the BH/HA cycle. This catalytic system has also been found useful to dehydrogenate indoles affording indolines that undergo in situ BH/HA cycle prior to re-aromatization, representing a tandem heterogeneous process.

Lewis acids catalyzed ring-opening reactions of methylenecyclopropanes and epoxides in supercritical carbon dioxide or modified supercritical carbon dioxide with perfluorocarbon

The reactions of methylenecyclopropanes (MCPs) and epoxides with alcohols and aromatic amines can be carried out in supercritical carbon dioxide (scCO2) or modified scCO2 with perfluorocarbon which offer a way to synthesize various alcohols, amino-alcohols, homoallylic ethers, and amines under an environmentally benign condition.