40201-94-3

Upstream product

• 4911-55-1 penta-1,3-diyne 
• 18292-02-9 1-trimethylsilyl-1,3-pentadiyne 
• 3876-63-9 1,1-dimethyl hexandiyn-2,4-ol 

Downstream Products

• 102747-66-0 1,1-bis-(4-dimethylamino-phenyl)-octa-2,4,6-triyn-1-ol 
• 4300-27-0 1-phenyl-hepta-1,3,5-triyne 
• 4453-99-0 2-<1-Hydroxyhexadiin-(2,4)-yl>-phenol 
• 24442-76-0 Decatetrain-(2.4.6.8) 

Relevant academic research and scientific papers

Synthesis of naturally occurring polyacetylenes via a bis-silylated diyne

A straightforward synthesis of a series of naturally occurring polyacetylenes has been developed, including the montiporynes A and C, possessing cytotoxic activity against several human solid tumor cells, the atractylodin, with antibiotic activity against Escherichia coli, and triynes, which display insecticidal activities, starting from the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne.

Stereoselective Total Syntheses of Polyacetylene Plant Metabolites via Ester-Tethered Ring Closing Metathesis

Total syntheses of five naturally occurring polyacetylenes from three different plants are described. These natural products have in common an E,Z-configured conjugated diene linked to a di- or triyne chain. As the key method to stereoselectively establis

Reactions of HDDA-Derived Benzynes with Sulfides: Mechanism, Modes, and Three-Component Reactions

We report here reactions of alkyl sulfides with benzynes thermally generated by the hexadehydro-Diels-Alder (HDDA) cycloisomerization. The initially produced 1,3-betaine (o-sulfonium/aryl carbanion) undergoes intramolecular proton transfer to generate a more stable S-aryl sulfur ylide. This can react in various manners, including engaging weak acids (HA) in the reaction medium. This can produce transient ion pairs ArSR2+A- that proceed to the products ArSR + RA. When cyclic sulfides are used, A- opens the ring and is incorporated into the product, an outcome that constitutes a versatile, three-component coupling process.