4022-35-9Relevant academic research and scientific papers
Fluorescent functionalised naphthalimides and their Au(i)-NHC complexes for potential use in cellular bioimaging
Groves, Lara M.,Ward, Benjamin D.,Symonds, Nadine O.,Pope, Simon J. A.,Williams, Catrin F.,Hayes, Anthony J.,Isaacs, Marc D.,Lloyd, David,Horton, Peter N.,Coles, Simon J.
, p. 1599 - 1612 (2019)
A series of cationic, dihydroimidazolinium-functionalized 1,8-naphthalimide fluorophores have been isolated as their hexafluorophosphate salts, [HL]PF6. These pro-ligands react with [AuCl(tht)] in the presence of base to form N-heterocyclic car
Synthesis and antidepressant-like activity evaluation of sulphonamides and sulphonyl-hydrazones
De Oliveira, Kely Navakoski,Costa, Philipe,Santin, José Roberto,Mazzambani, Leonor,Bürger, Cristiani,Mora, Cristiano,Nunes, Ricardo José,De Souza, Márcia Maria
experimental part, p. 4295 - 4306 (2011/08/21)
In this study a series of sulphonamides and sulphonyl hydrazones of maleimide, naphthalimide and phthalimide derivatives was synthesized. The antidepressant effect of these compounds was evaluated by the forced-swimming test in mice. The behavioural parameter observed in this test is a reduction in the immobility time, which is indicative of antidepressant activity. All compounds, except 8, 11 and 24, were active as antidepressants. The most active compound was the sulphonyl-hydrazone 10 which showed an activity of around 72.02% at 60 mg/kg, it thus being more active than imipramine (10 mg/kg, ip), a commercial antidepressant. Other important results were obtained for the benzylnaphthalimide derivatives, the sulphonamides 21 and 22 showing activity of 64% at 10 mg/kg, also being more active than imipramine. These results indicate that the sulphonamides and sulphonyl-hydrazone cyclic imide derivatives are potential compounds for use in the designing of new candidates for the treatment of depression.
Evaluation of apoptotic effect of cyclic imide derivatives on murine B16F10 melanoma cells
Machado, Karina Elisa,De Oliveira, Kely Navakoski,Santos-Bubniak, Lorena,Licínio, Marley Aparecida,Nunes, Ricardo José,Santos-Silva, Maria Cláudia
scheme or table, p. 6285 - 6291 (2011/12/14)
Cyclic imides are a large class of compounds obtained by organic synthesis including several sub-classes (succinimides maleimide, glutarimide, phthalimides naphtalimides, and its derivatives). Recently, some cyclic imide derivatives have shown important results as potential antitumor agents, as a Mitonafide and Amonafide. Based on this fact, we have studied antitumoral properties of nine cyclic imide derivatives, four of which are unpublished compounds, against Murine Melanoma Cells (B16F10). Initially, the MTT assay was used to select the compound with the best cytotoxic potential. After this selection, the compound 2-benzyl-1H-benzo[de]isoquinoline-1,3(2H)-dione (4), which showed the best cytotoxic effects, was evaluated by flow cytometry, and a significant increase was observed in the proportion of cells in the subG0/G1, S and G2/M phases accompanied by a significant decrease in the G0/G1 phases. Then the mechanism involved on the death route (necrosis or apoptosis) was evaluated the by bromide and acridine orange method and by an Annexin V-FITC Apoptosis Detection kit. These results confirm that the percentage of B16F10 cells observed in the sub G0/G1 phase were undergoing apoptosis. The biological effects observed in the current study for the cyclic imide derivatives suggested promising applications, especially for the prototype compound 4.
