40230-92-0

Basic information

• Product Name: ((3-METHOXYPHENYL)ETHYNYL)-TRIMETHYLSIL&
• Synonyms: ((3-METHOXYPHENYL)ETHYNYL)-TRIMETHYLSIL&;(3-METHOXYPHENYLETHYNYL)-TRIMETHYLSILAN&
• CAS NO: 40230-92-0
• Molecular Formula: C₁₂H₁₆OSi
• Molecular Weight: 204.34034
• Product Categories: Alkynes;Internal;Organic Building Blocks
• Mol File: 40230-92-0.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 65-70 °C0.1 mm Hg(lit.)
• Flash Point: 135 °F
• Appearance: /
• Density: 0.940 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0322mmHg at 25°C
• Refractive Index: n20/D 1.5360(lit.)
• CAS DataBase Reference: ((3-METHOXYPHENYL)ETHYNYL)-TRIMETHYLSIL&(CAS DataBase Reference)
• NIST Chemistry Reference: ((3-METHOXYPHENYL)ETHYNYL)-TRIMETHYLSIL&(40230-92-0)
• EPA Substance Registry System: ((3-METHOXYPHENYL)ETHYNYL)-TRIMETHYLSIL&(40230-92-0)

Safety Data

• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 40230-92-0(Hazardous Substances Data)

Usage

General Description

The chemical compound ((3-methoxyphenyl)ethynyl)-trimethylsilane is a derivative of trimethylsilyl acetylene with a 3-methoxyphenyl group attached to the acetylene carbon. ((3-METHOXYPHENYL)ETHYNYL)-TRIMETHYLSIL& is used in organic synthesis as a building block for the preparation of various functionalized organic molecules. It is commonly used as a reagent in the Sonogashira coupling reaction, a widely used method for the synthesis of carbon-carbon bonds. Additionally, ((3-methoxyphenyl)ethynyl)-trimethylsilane has applications in the preparation of pharmaceuticals, agrochemicals, and materials science. Its unique structure and reactivity make it a valuable tool for the synthesis of complex organic molecules.

InChI:InChI=1/C12H16OSi/c1-13-12-7-5-6-11(10-12)8-9-14(2,3)4/h5-7,10H,1-4H3

Upstream product

• 766-85-8 3-methoxy-1-iodobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 2398-37-0 3-methoxyphenyl bromide 

Downstream Products

• 111727-07-2 1-methoxy-3-(3,3,3-trifluoroprop-1-yn-1-yl)benzene 
• 1145987-34-3 2,5-bis(3-methoxyphenyl)furan 

Relevant articles and documents

Ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity

ortho-Carboranylphenoxy derivatives were synthesized and evaluated for their ability to inhibit hypoxia-induced HIF-1 transcriptional activity using a cell-based reporter gene assay. Among the compounds synthesized, compound 1d showed the most significant

Enantioselective synthesis of β-fluoro-β-aryl-α-aminopentenamides by organocatalytic [2,3]-sigmatropic rearrangement

The tetramisole-promoted catalytic enantioselective [2,3]-sigmatropic rearrangement of quaternary ammonium salts bearing a (Z)-3-fluoro-3-arylprop-2-ene group generates, after addition of benzylamine, a range of β-fluoro-β-aryl-α-aminopentenamides containing a stereogenic tertiary fluorine substituent. Cyclic and acyclic nitrogen substituents as well as various aromatic substituents are tolerated, giving the β-fluoro-β-aryl-α-aminopentenamide products in up to 76% yield, 96:4 dr, and 98:2 er.

Microwave-assisted copper- and palladium-catalyzed sonogashira-type coupling of aryl bromides and iodides with trimethylsilylacetylene

An efficient and rapid method was developed for the synthesis of 1-aryl-2-(trimethylsilyl)acetylene. Copper and palladium-catalyzed sonogashira-type coupling of trimethylsilylacetylene and aryl bromides or iodides in the presence of triethylamine as base