40240-74-2

Upstream product

• 125521-28-0 dimethyl-phenacyl-(4-phenyl-phenacyl)-ammonium; bromide 
• 40240-57-1 4-Biphenyl-4-yl-2-hydroxy-1-phenyl-butane-1,4-dione 
• 1074-12-0 phenylglyoxal hydrate 
• 40240-62-8 1-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)pyridin-1-ium bromide 
• 31378-03-7 1-phenyl-2-tosylethanone 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 2959-60-6 1-([1,1'-biphenyl]-4-yl)-2-(triphenyl-λ⁵-phosphaneylidene)ethan-1-one 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 879007-38-2 1-biphenyl-4-yl-4-phenyl-but-2c-ene-1,4-dione 

Relevant academic research and scientific papers

Aerobic Oxidative Dehydrogenation of Ketones to 1,4-Enediones

An efficient and unprecedented strategy for the synthesis of 1,4-enediones from saturated ketones has been developed via palladium-catalyzed oxidative dehydrogenation. The protocol employs molecular oxygen as the sole oxidant and represents an atom- and step-economic process. The approach showed broad substrate scope, good functional group tolerance, and complete E-stereoselectivity. The reaction mechanism has been investigated through deuterium-labeling experiments and intermediate experiments.

Synthesis of (E)-1,4-diaryl-2-butene-1,4-diones

We report a facile route for the preparation of symmetric and unsymmetric (E)-1,4-diaryl-2-butene-1,4-diones 3 by a two-step route, including (1) nucleophilic substitution of 1 with sulfinic acid sodium salts, and (2) K2CO3 mediated alkylation of β-ketosulfones 4 with 1 followed by sequential desulfonylation of the resulting 1,4-diketones 5 in acetone. These products were obtained in high yields.