402483-49-2

Upstream product

• 72995-94-9 14-bromotetradecan-1-ol 
• 220757-91-5 1,1-(ethylenedioxy)-4-methyl-3-(phenylsulfonyl)-cyclohexane 
• 75337-05-2 4-methyl-2-cyclohexenone 
• 519-73-3 triphenylmethane 
• 589-92-4 1-methylcyclohexan-4-one 
• 821-38-5 1,14-tetradecanedioic acid 
• 19812-64-7 1,14-tetradecanediol 
• 220757-90-4 4-methyl-3-(phenylsulfonyl)-cyclohexan-1-one 
• 873-55-2 sodium benzenesulfonate 

Relevant academic research and scientific papers

Stem cell differentiation-inducing promoter

Provided is a stem-cell differentiation and induction promoter, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the formula (1):[wherein, R1, R2 and R3 each indepen

Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators

Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.

Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship

Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω-alkanol side chain were synthesized using 'Umpolung' reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω-hydroxy side chain is a crucial factor for biological activity.